Table 3 Known-groups validity of mean weekly RS-total and subscales at baseline in 205715/205832
Patient groups | 205715a | 205832 | ||||||
|---|---|---|---|---|---|---|---|---|
Total (n, mean [SD]) | Breathlessness (n, mean [SD]) | Cough and sputum (n, mean [SD]) | Chest symptoms (n, mean (SD)) | Total (n, mean [SD]) | Breathlessness (n, mean [SD]) | Cough and sputum (n, mean [SD]) | Chest symptoms (n, mean [SD]) | |
Exacerbation history (number) | ||||||||
≥ 2 | 638, 9.19 (0.25) | 638, 4.44 (0.13) | 638, 2.40 (0.07) | 638, 2.35 (0.07) | 26, 8.46 (1.11) | 26, 3.95 (0.59) | 26, 2.28 (0.30) | 26, 2.23 (0.34) |
1 | 1284, 7.86 (0.18) | 1284, 3.76 (0.09) | 1284, 2.13 (0.05) | 1284, 1.97 (0.05) | 71, 7.41 (0.67) | 71, 3.42 (0.36) | 71, 2.11 (0.18) | 71, 1.88 (0.20) |
0 | 317, 8.15 (0.35) | 317, 3.85 (0.18) | 317, 2.19 (0.10) | 317, 2.11 (0.10) | 323, 7.06 (0.31) | 323, 3.43 (0.17) | 323, 1.82 (0.09) | 323, 1.80 (0.10) |
F-test statistic | 9.64 | 9.38 | 5.23 | 8.87 | 0.80 | 0.36 | 1.84 | 0.79 |
P-value | < 0.0001 | < 0.0001 | 0.0054 | 0.0001 | 0.4497 | 0.6961 | 0.1608 | 0.4551 |
FEV1% predicted | ||||||||
Mild (≥80%) | 448, 6.59 (0.29) | 448, 3.00 (0.15) | 448, 1.91 (0.08) | 448, 1.67 (0.09) | 102, 7.06 (0.56) | 102, 3.19 (0.30) | 102, 1.98 (0.15) | 102, 1.88 (0.17) |
Moderate (50–< 80%) | 1469, 8.34 (0.16) | 1469, 4.02 (0.08) | 1469, 2.20 (0.05) | 1469, 2.12 (0.05) | 298, 7.09 (0.33) | 298, 3.47 (0.17) | 298, 1.82 (0.09) | 298, 1.80 (0.10) |
Severe (30–< 50%) | 282, 10.64 (0.37) | 282, 5.17 (0.19) | 282, 2.79 (0.10) | 282, 2.68 (0.11) | 19, 10.07 (1.29) | 19, 4.92 (0.68) | 19, 2.77 (0.35) | 19, 2.38 (0.39) |
Very severe (< 30%) | 9, 13.26 (2.06) | 9, 6.83 (1.07) | 9, 3.34 (0.58) | 9, 3.09 (0.62) | 0, N/A | 0, N/A | 0, N/A | 0, N/A |
F-test statistic | 26.85 | 29.03 | 16.16 | 18.41 | 2.55 | 2.71 | 3.54 | 1.07 |
P-value | < 0.0001 | < 0.0001 | < 0.0001 | < 0.0001 | 0.0794 | 0.0678 | 0.0300 | 0.3429 |
PGI-S | ||||||||
None | 52, 1.87 (0.81) | 52, 0.81 (0.42) | 52, 0.67 (0.23) | 52, 0.40 (0.24) | 5, 3.40 (2.38) | 5, 1.07 (1.27) | 5, 1.38 (0.67) | 5, 0.96 (0.73) |
Mild | 687, 5.36 (0.22) | 687, 2.46 (0.12) | 687, 1.53 (0.06) | 687, 1.37 (0.07) | 197, 5.34 (0.38) | 197, 2.53 (0.20) | 197, 1.48 (0.11) | 197, 1.33 (0.12) |
Moderate | 1384, 9.62 (0.16) | 1384, 4.64 (0.08) | 1384, 2.55 (0.04) | 1384, 2.43 (0.05) | 213, 8.84 (0.37) | 213, 4.29 (0.19) | 213, 2.27 (0.10) | 213, 2.28 (0.11) |
Severe | 97, 13.39 (0.59) | 97, 6.58 (0.31) | 97, 3.26 (0.17) | 97, 3.55 (0.18) | 5, 14.47 (2.38) | 5, 7.11 (1.27) | 5, 2.98 (0.67) | 5, 4.38 (0.73) |
Very severe | 1, 22.60 (5.82) | 1, 10.00 (3.04) | 1, 6.20 (1.65) | 1, 6.40 (1.77) | 0, N/A | 0, N/A | 0, N/A | 0, N/A |
F-test statistic | 97.27 | 91.94 | 66.37 | 70.99 | 18.66 | 17.16 | 10.48 | 16.19 |
P-value | < 0.0001 | < 0.0001 | < 0.0001 | < 0.0001 | < 0.0001 | < 0.0001 | < 0.0001 | < 0.0001 |