Table 10 Summary of HPES-Impact and HPES-Symptom Scales for TransCon PTH vs. placebo by ANCOVA (Full analysis set; N = 59)
From: Psychometric validation of the Hypoparathyroidism Patient Experience Scales (HPES)
HPES | TransCon PTH All Subjects (n = 44) | Placebo (n = 15) |
|---|---|---|
HPES-Impact | ||
Daily life domain, n | 44 | 15 |
 Baseline, mean (SE) | 29.6 (3.9) | 36.8 (7.4) |
 Week 4, mean (SE) | 13.5 (2.5) | 35.7(9.9) |
 LS Mean (SE) | −16.8 (2.7) | 0.8 (4.6) |
 Difference in LS Mean (SE) | −17.7 (5.3) |  |
 P value | 0.0015 |  |
Physical functioning domain (n) | 44 | 15 |
 Baseline, mean (SE) | 32.6 (3.9) | 41.3 (7.6) |
 Week 4, mean (SE) | 17.7 (3.0) | 38.9 (9.3) |
 LS Mean (SE) | −15.8 (2.9) | 0.3 (5.1) |
 Difference in LS mean (SE) | −16.1 (5.8) |  |
 P value | 0.0077 |  |
Psychological Well-Being Domain (n) | 44 | 15 |
 Baseline, mean (SE) | 24.8 (3.3) | 25.0 (6.2) |
 Week 4, mean (SE) | 12.4 (2.3) | 25.0 (7.1) |
 LS Mean (SE) | −12.5 (2.6) | 0.1 (4.5) |
 Difference in LS mean (SE) | −12.6 (5.1) |  |
 P value | 0.0163 |  |
Social life and relationship domain (n) | 44 | 15 |
 Baseline, mean (SE) | 22.0 (3.4) | 24.7 (5.6) |
 Week 4, mean (SE) | 10.6 (2.6) | 29.0 (9.8) |
 LS mean (SE) | −11.7 (2.8) | 4.9 (4.9) |
 Difference in LS mean (SE) | −16.6 (5.6) |  |
 P value | 0.0045 |  |
Total HPES-Impact score (n) | 44 | 15 |
 Baseline, mean (SE) | 27.3 (3.3) | 32.0 (5.8) |
 Week 4, mean (SE) | 13.5 (2.3) | 32.1 (8.7) |
 LS mean (SE) | −14.2 (2.5) | 1.5 (4.3) |
 Difference in LS mean (SE) | −15.7 (5.0) |  |
 P value | 0.0026 |  |
HPES-Symptom | ||
Physical Domain (n) | 44 | 15 |
 Baseline, mean (SE) | 37.3 (3.2) | 43.2 (6.3) |
 Week 4, mean (SE) | 20.3 (2.3) | 42.1 (8.4) |
 LS Mean (SE) | −17.5 (2.3) | 0.4 (4.0) |
 Difference in LS Mean (SE) | −18.1 (4.6) |  |
 P value | 0.0003 |  |
Cognitive Domain (n) | 44 | 15 |
 Baseline, mean (SE) | 38.6 (4.7) | 34.7 (7.5) |
 Week 4, mean (SE) | 20.5 (3.0) | 39.7 (6.9) |
 LS Mean (SE) | −17.6 (2.8) | 3.2 (4.9) |
 Difference in LS Mean (SE) | −20.8 (5.6) |  |
 P value | 0.0005 |  |
Total HPES-Symptom Score (n) | 44 | 15 |
 Baseline, mean (SE) | 38.0 (3.5) | 38.9 (5.4) |
 Week 4, mean (SE) | 20.4 (2.4) | 40.9 (7.2) |
 LS Mean (SE) | −17.7 (2.3) | 2.3 (4.0) |
 Difference in LS Mean (SE) | −20.0 (4.6) |  |
 P value | < 0.0001 |  |