Table 2 Outcomesa over time for analyzed patients
EORTC (N = 133) | SEIQOL (N = 134) | Total (N = 267) | P-value | |
|---|---|---|---|---|
FACIT-SP Total | ||||
Baseline | ||||
Mean (SD) | 100.7 (17.4) | 102.4 (17.0) | 101.6 (17.2) | 0.396 |
Median | 103.7 | 101.8 | 103 | |
Q1 & Q3 | 92 to 113 | 92 to 114.2 | 92 to 113.9 | |
n | 133 | 134 | 267 | |
2nd questionnaire | ||||
Mean (SD) | 101.8 (18.4) | 100.6 (17.4) | 101.2 (17.9) | 0.588 |
Median | 104.5 | 100.5 | 101.8 | |
Q1 & Q3 | 88.5 to 115.9 | 88 to 112.7 | 88 to 115 | |
n | 126 | 130 | 256 | |
4 months | ||||
Mean (SD) | 101.6 (16.3) | 99.1 (16.6) | 100.4 (16.5) | 0.289 |
Median | 102.3 | 101.1 | 102 | |
Q1 & Q3 | 88.8 to 114.2 | 87.5 to 111.4 | 88.1 to 113 | |
n | 101 | 98 | 199 | |
FACIT PWB | ||||
Baseline | ||||
Mean (SD) | 21.0 (5.3) | 20.9 (5.6) | 20.9 (5.4) | 0.959 |
Median | 22 | 22 | 22 | |
Q1 & Q3 | 18 to 25 | 17 to 25.7 | 18 to 25 | |
n | 131 | 133 | 264 | |
2nd questionnaire | ||||
Mean (SD) | 20.6 (5.9) | 20.3 (5.1) | 20.4 (5.5) | 0.678 |
Median | 22 | 21 | 21 | |
Q1 & Q3 | 17 to 25 | 16 to 24.1 | 17 to 25 | |
n | 125 | 128 | 253 | |
4 months | ||||
Mean (SD) | 20.0 (5.9) | 19.6 (5.8) | 19.8 (5.8) | 0.689 |
Median | 21 | 21 | 21 | |
Q1 & Q3 | 16 to 25 | 16 to 24 | 16 to 25 | |
n | 101 | 98 | 199 | |
FACIT SWB | ||||
Baseline | ||||
Mean (SD) | 23.8 (3.5) | 23.5 (3.7) | 23.6 (3.6) | 0.402 |
Median | 24 | 24 | 24 | |
Q1 & Q3 | 22 to 26.8 | 21 to 26 | 21 to 26.4 | |
n | 130 | 133 | 263 | |
2nd questionnaire | ||||
Mean (SD) | 23.6 (4.5) | 22.6 (3.7) | 23.1 (4.2) | 0.074 |
Median | 25 | 23 | 24 | |
Q1 & Q3 | 21 to 26.8 | 20 to 25.3 | 21 to 26 | |
n | 125 | 128 | 253 | |
4 months | ||||
Mean (SD) | 23.2 (4.2) | 22.7 (4.5) | 23.0 (4.3) | 0.413 |
Median | 24 | 24 | 24 | |
Q1 & Q3 | 21 to 26.8 | 21 to 25.7 | 21 to 26 | |
n | 101 | 98 | 199 | |
FACIT EWB | ||||
Baseline | ||||
Mean (SD) | 6.6 (4.6) | 6.3 (4.3) | 6.5 (4.4) | 0.634 |
Median | 5 | 6 | 5 | |
Q1 & Q3 | 3 to 9.2 | 3 to 9 | 3 to 9 | |
n | 132 | 133 | 265 | |
2nd questionnaire | ||||
Mean (SD) | 5.6 (4.5) | 5.9 (4.7) | 5.7 (4.6) | 0.566 |
Median | 5 | 5 | 5 | |
Q1 & Q3 | 2 to 8 | 2 to 9.2 | 2 to 9 | |
n | 125 | 128 | 253 | |
4 months | ||||
Mean (SD) | 6.3 (5.0) | 6.7 (4.9) | 6.5 (5.0) | 0.578 |
Median | 5 | 6 | 5 | |
Q1 & Q3 | 2 to 9 | 3 to 9.8 | 3 to 9 | |
n | 101 | 98 | 199 | |
FACIT FWB | ||||
Baseline | ||||
Mean (SD) | 17.3 (5.4) | 18.2 (5.8) | 17.8 (5.6) | 0.172 |
Median | 18 | 19 | 19 | |
Q1 & Q3 | 14.8 to 21 | 14 to 23 | 14 to 22 | |
n | 132 | 133 | 265 | |
2nd questionnaire | ||||
Mean (SD) | 17.9 (5.9) | 17.7 (5.7) | 17.8 (5.8) | 0.724 |
Median | 19 | 18 | 18 | |
Q1 & Q3 | 13 to 23 | 14 to 21 | 13 to 22 | |
n | 125 | 128 | 253 | |
4 months | ||||
Mean (SD) | 17.4 (6.1) | 17.2 (5.6) | 17.3 (5.8) | 0.785 |
Median | 18 | 18 | 18 | |
Q1 & Q3 | 13 to 22 | 14 to 21 | 13 to 21 | |
n | 101 | 98 | 199 | |
FACIT SPS | ||||
Baseline | ||||
Mean (SD) | 33.5 (8.0) | 35.1 (8.5) | 34.3 (8.3) | 0.132 |
Median | 33.3 | 36 | 34.7 | |
Q1 & Q3 | 28 to 39.7 | 29.3 to 41.3 | 29 to 41 | |
n | 131 | 130 | 261 | |
2nd questionnaire | ||||
Mean (SD) | 35.0 (9.1) | 35.1 (8.2) | 35.0 (8.6) | 0.898 |
Median | 37 | 36 | 36 | |
Q1 & Q3 | 28 to 42.7 | 29.6 to 41.8 | 28 to 42 | |
n | 125 | 130 | 255 | |
4 months | ||||
Mean (SD) | 34.7 (8.4) | 33.6 (8.9) | 34.2 (8.7) | 0.363 |
Median | 36 | 34.2 | 35 | |
Q1 & Q3 | 28 to 41.3 | 26.7 to 40.2 | 27 to 41.1 | |
n | 101 | 96 | 197 | |
FACIT FG Total | ||||
Baseline | ||||
Mean (SD) | 68.1 (11.4) | 68.4 (10.0) | 68.3 (10.7) | 0.830 |
Median | 69 | 69.8 | 69.2 | |
Q1 & Q3 | 62 to 76.7 | 61.7 to 76 | 62 to 76 | |
n | 132 | 134 | 266 | |
2nd questionnaire | ||||
Mean (SD) | 67.6 (10.9) | 66.5 (10.3) | 67.1 (10.6) | 0.392 |
Median | 68.2 | 67.2 | 68 | |
Q1 & Q3 | 60 to 76 | 59.7 to 75 | 59.8 to 75.8 | |
n | 125 | 128 | 253 | |
4 months | ||||
Mean (SD) | 66.9 (11.1) | 66.2 (9.8) | 66.5 (10.5) | 0.653 |
Median | 69 | 66.2 | 67 | |
Q1 & Q3 | 59 to 75.3 | 60 to 74 | 59 to 74.8 | |
n | 101 | 98 | 199 | |
MISS-21 Total | ||||
Baseline | ||||
Mean (SD) | 5.9 (0.9) | 6.0 (0.8) | 5.9 (0.8) | 0.422 |
Median | 6.1 | 6.2 | 6.1 | |
Q1 & Q3 | 5.4 to 6.6 | 5.4 to 6.6 | 5.4 to 6.6 | |
n | 133 | 134 | 267 | |
2nd questionnaire | ||||
Mean (SD) | 6.0 (0.8) | 5.9 (0.8) | 6.0 (0.8) | 0.402 |
Median | 6.2 | 6.1 | 6.1 | |
Q1 & Q3 | 5.6 to 6.6 | 5.5 to 6.6 | 5.6 to 6.6 | |
n | 127 | 131 | 258 | |
4 months | ||||
Mean (SD) | 5.9 (1.0) | 5.9 (0.8) | 5.9 (0.9) | 0.807 |
Median | 6.3 | 6.1 | 6.2 | |
Q1 & Q3 | 5.4 to 6.7 | 5.5 to 6.5 | 5.4 to 6.6 | |
n | 101 | 98 | 199 | |
MISS-21 Distress Relief | ||||
Baseline | ||||
Mean (SD) | 5.4 (1.3) | 5.5 (1.3) | 5.4 (1.3) | 0.900 |
Median | 5.7 | 5.8 | 5.8 | |
Q1 & Q3 | 4.8 to 6.3 | 4.8 to 6.3 | 4.8 to 6.3 | |
n | 132 | 134 | 266 | |
2nd questionnaire | ||||
Mean (SD) | 5.5 (1.3) | 5.4 (1.2) | 5.5 (1.3) | 0.620 |
Median | 5.7 | 5.7 | 5.7 | |
Q1 & Q3 | 5 to 6.5 | 4.7 to 6.5 | 4.8 to 6.5 | |
n | 127 | 130 | 257 | |
4 months | ||||
Mean (SD) | 5.6 (1.4) | 5.5 (1.2) | 5.5 (1.3) | 0.582 |
Median | 6 | 5.8 | 5.8 | |
Q1 & Q3 | 5 to 6.7 | 4.8 to 6.2 | 4.8 to 6.6 | |
n | 101 | 98 | 199 | |
MISS-21 Communciation Comfort | ||||
Baseline | ||||
Mean (SD) | 6.0 (1.2) | 6.1 (0.9) | 6.0 (1.0) | 0.413 |
Median | 6.2 | 6.2 | 6.2 | |
Q1 & Q3 | 5.5 to 7 | 5.5 to 7 | 5.5 to 7 | |
n | 133 | 134 | 267 | |
2nd questionnaire | ||||
Mean (SD) | 6.1 (1.0) | 6.1 (0.9) | 6.1 (1.0) | 0.975 |
Median | 6.5 | 6.2 | 6.5 | |
Q1 & Q3 | 5.5 to 7 | 5.5 to 7 | 5.5 to 7 | |
n | 127 | 131 | 258 | |
4 months | ||||
Mean (SD) | 5.9 (1.2) | 6.1 (1.0) | 6.0 (1.1) | 0.243 |
Median | 6.2 | 6.5 | 6.2 | |
Q1 & Q3 | 5.5 to 7 | 5.5 to 7 | 5.5 to 7 | |
n | 101 | 98 | 199 | |
MISS-21 Rapport | ||||
Baseline | ||||
Mean (SD) | 6.1 (1.0) | 6.2 (0.9) | 6.2 (0.9) | 0.648 |
Median | 6.5 | 6.4 | 6.5 | |
Q1 & Q3 | 5.8 to 6.9 | 5.9 to 6.9 | 5.8 to 6.9 | |
n | 133 | 134 | 267 | |
2nd questionnaire | ||||
Mean (SD) | 6.3 (0.9) | 6.1 (1.0) | 6.2 (0.9) | 0.129 |
Median | 6.6 | 6.4 | 6.6 | |
Q1 & Q3 | 5.9 to 7 | 5.8 to 6.9 | 5.9 to 6.9 | |
n | 127 | 131 | 258 | |
4 months | ||||
Mean (SD) | 6.2 (1.2) | 6.1 (1.0) | 6.1 (1.1) | 0.538 |
Median | 6.8 | 6.2 | 6.5 | |
Q1 & Q3 | 5.9 to 7 | 5.9 to 6.9 | 5.9 to 7 | |
n | 101 | 98 | 199 | |
MISS-21 Compliance Intent | ||||
Baseline | ||||
Mean (SD) | 6.0 (1.1) | 6.3 (0.9) | 6.2 (1.0) | 0.073 |
Median | 6.4 | 6.7 | 6.7 | |
Q1 & Q3 | 5.3 to 7 | 6 to 7 | 5.7 to 7 | |
n | 130 | 132 | 262 | |
2nd questionnaire | ||||
Mean (SD) | 6.1 (1.2) | 6.1 (1.1) | 6.1 (1.2) | 0.991 |
Median | 6.7 | 6.3 | 6.4 | |
Q1 & Q3 | 5.3 to 7 | 5.3 to 7 | 5.3 to 7 | |
n | 125 | 129 | 254 | |
4 months | ||||
Mean (SD) | 6.0 (1.3) | 6.0 (1.1) | 6.0 (1.2) | 0.782 |
Median | 6.3 | 6.3 | 6.3 | |
Q1 & Q3 | 5 to 7 | 5 to 7 | 5 to 7 | |
n | 100 | 96 | 196 | |
Perceived Quality of Communication (PQC VAS) | ||||
Baseline | ||||
Mean (SD) | 85.3 (15.4) | 85.7 (13.4) | 85.5 (14.4) | 0.794 |
Median | 89.5 | 90 | 90 | |
Q1 & Q3 | 81.8 to 96 | 78.5 to 96 | 80 to 96 | |
n | 128 | 127 | 255 | |
2nd questionnaire | ||||
Mean (SD) | 86.1 (14.3) | 85.6 (16.7) | 85.8 (15.5) | 0.794 |
Median | 90 | 91 | 91 | |
Q1 & Q3 | 81.5 to 97 | 80 to 96 | 80.2 to 96.8 | |
n | 123 | 127 | 250 | |
4 months | ||||
Mean (SD) | 83.2 (19.0) | 84.9 (13.6) | 84.0 (16.5) | 0.481 |
Median | 90.5 | 87.5 | 89 | |
Q1 & Q3 | 78.8 to 96 | 78 to 95 | 78 to 96 | |
n | 96 | 94 | 190 | |
Global Quality of Life Uniscale (GQL VAS) | ||||
Baseline | ||||
Mean (SD) | 63.3 (21.5) | 68.2 (21.2) | 65.8 (21.4) | 0.062 |
Median | 68 | 71 | 70 | |
Q1 & Q3 | 49 to 79 | 53.8 to 84 | 50 to 82 | |
n | 129 | 132 | 261 | |
2nd questionnaire | ||||
Mean (SD) | 65.3 (23.3) | 67.7 (21.9) | 66.5 (22.6) | 0.394 |
Median | 70 | 71 | 70 | |
Q1 & Q3 | 49 to 83 | 51.5 to 84.8 | 50 to 83.5 | |
n | 125 | 130 | 255 | |
4 months | ||||
Mean (SD) | 64.3 (24.8) | 66.7 (21.9) | 65.5 (23.4) | 0.469 |
Median | 71 | 71 | 71 | |
Q1 & Q3 | 47 to 82 | 54 to 82 | 49.8 to 82 | |
n | 101 | 95 | 196 | |
PGIC 1 – Overall QoL change | ||||
Baseline | ||||
Mean (SD) | 0.1 (3.7) | 0.8 (3.8) | 0.4 (3.8) | 0.128 |
Median | 0 | 0 | 0 | |
Q1 & Q3 | -3 to 4 | 0 to 4.8 | 0 to 4 | |
n | 132 | 130 | 262 | |
2nd questionnaire | ||||
Mean (SD) | 0.6 (3.5) | 0.8 (3.3) | 0.7 (3.4) | 0.591 |
Median | 0 | 0 | 0 | |
Q1 & Q3 | 0 to 4 | 0 to 4 | 0 to 4 | |
n | 125 | 129 | 254 | |
4 months | ||||
Mean (SD) | 0.2 (3.5) | 0.7 (3.4) | 0.4 (3.4) | 0.265 |
Median | 0 | 0 | 0 | |
Q1 & Q3 | 0 to 2 | 0 to 4 | 0 to 4 | |
n | 101 | 98 | 199 | |
MISS-21 item 1 | ||||
Baseline | ||||
Mean (SD) | 5.5 (1.4) | 5.3 (1.5) | 5.4 (1.5) | 0.253 |
Median | 6 | 6 | 6 | |
Q1 & Q3 | 5 to 7 | 4 to 7 | 4 to 7 | |
n | 125 | 126 | 251 | |
2nd questionnaire | ||||
Mean (SD) | 5.3 (1.7) | 5.2 (1.6) | 5.3 (1.6) | 0.682 |
Median | 6 | 6 | 6 | |
Q1 & Q3 | 4 to 7 | 4.5 to 6 | 4 to 7 | |
n | 121 | 123 | 244 | |
4 months | ||||
Mean (SD) | 5.7 (1.4) | 5.3 (1.5) | 5.5 (1.5) | 0.077 |
Median | 6 | 6 | 6 | |
Q1 & Q3 | 5 to 7 | 4 to 6 | 4 to 7 | |
n | 98 | 93 | 191 | |
MISS-21 item 2 | ||||
Baseline | ||||
Mean (SD) | 5.5 (1.6) | 5.5 (1.8) | 5.5 (1.7) | 0.981 |
Median | 6 | 6 | 6 | |
Q1 & Q3 | 5 to 7 | 4 to 7 | 4 to 7 | |
n | 126 | 129 | 255 | |
2nd questionnaire | ||||
Mean (SD) | 5.5 (1.7) | 5.5 (1.7) | 5.5 (1.7) | 0.989 |
Median | 6 | 6 | 6 | |
Q1 & Q3 | 4.5 to 7 | 5 to 7 | 5 to 7 | |
n | 123 | 120 | 243 | |
4 months | ||||
Mean (SD) | 5.5 (1.8) | 5.6 (1.6) | 5.5 (1.7) | 0.891 |
Median | 6 | 6 | 6 | |
Q1 & Q3 | 4.2 to 7 | 5 to 7 | 5 to 7 | |
n | 98 | 94 | 192 | |
MISS-21 item 3 | ||||
Baseline | ||||
Mean (SD) | 5.6 (1.7) | 5.5 (1.8) | 5.5 (1.7) | 0.652 |
Median | 6 | 6 | 6 | |
Q1 & Q3 | 5 to 7 | 4 to 7 | 5 to 7 | |
n | 130 | 127 | 257 | |
2nd questionnaire | ||||
Mean (SD) | 5.7 (1.6) | 5.5 (1.7) | 5.6 (1.7) | 0.482 |
Median | 6 | 6 | 6 | |
Q1 & Q3 | 5 to 7 | 4 to 7 | 5 to 7 | |
n | 125 | 119 | 244 | |
4 months | ||||
Mean (SD) | 5.8 (1.6) | 5.7 (1.5) | 5.7 (1.5) | 0.648 |
Median | 6 | 6 | 6 | |
Q1 & Q3 | 5 to 7 | 5 to 7 | 5 to 7 | |
n | 97 | 94 | 191 | |
MISS-21 item 4 | ||||
Baseline | ||||
Mean (SD) | 3.4 (2.4) | 3.4 (2.4) | 3.4 (2.4) | 0.901 |
Median | 2 | 2 | 2 | |
Q1 & Q3 | 1 to 6 | 1 to 6 | 1 to 6 | |
n | 127 | 125 | 252 | |
2nd questionnaire | ||||
Mean (SD) | 2.7 (2.2) | 3.1 (2.2) | 2.9 (2.2) | 0.261 |
Median | 2 | 2 | 2 | |
Q1 & Q3 | 1 to 4.5 | 1 to 5 | 1 to 5 | |
n | 123 | 124 | 247 | |
4 months | ||||
Mean (SD) | 3.3 (2.4) | 3.0 (2.2) | 3.2 (2.3) | 0.262 |
Median | 2 | 2 | 2 | |
Q1 & Q3 | 1 to 6 | 1 to 4 | 1 to 6 | |
n | 99 | 93 | 192 | |
MISS-21 item 5 | ||||
Baseline | ||||
Mean (SD) | 5.1 (1.8) | 5.2 (1.7) | 5.1 (1.8) | 0.626 |
Median | 6 | 6 | 6 | |
Q1 & Q3 | 4 to 7 | 4 to 7 | 4 to 7 | |
n | 126 | 128 | 254 | |
2nd questionnaire | ||||
Mean (SD) | 5.2 (1.7) | 5.1 (1.8) | 5.1 (1.7) | 0.727 |
Median | 6 | 6 | 6 | |
Q1 & Q3 | 4 to 6.8 | 4 to 7 | 4 to 7 | |
n | 122 | 118 | 240 | |
4 months | ||||
Mean (SD) | 5.5 (1.7) | 5.4 (1.6) | 5.5 (1.6) | 0.489 |
Median | 6 | 6 | 6 | |
Q1 & Q3 | 5 to 7 | 5 to 7 | 5 to 7 | |
n | 98 | 95 | 193 | |
MISS-21 item 6 | ||||
Baseline | ||||
Mean (SD) | 5.7 (1.4) | 5.7 (1.4) | 5.7 (1.4) | 0.945 |
Median | 6 | 6 | 6 | |
Q1 & Q3 | 5 to 7 | 5 to 7 | 5 to 7 | |
n | 131 | 133 | 264 | |
2nd questionnaire | ||||
Mean (SD) | 5.8 (1.4) | 5.7 (1.4) | 5.8 (1.4) | 0.338 |
Median | 6 | 6 | 6 | |
Q1 & Q3 | 5 to 7 | 5 to 7 | 5 to 7 | |
n | 127 | 129 | 256 | |
4 months | ||||
Mean (SD) | 6.0 (1.4) | 5.6 (1.5) | 5.8 (1.4) | 0.064 |
Median | 7 | 6 | 6 | |
Q1 & Q3 | 5 to 7 | 5 to 7 | 5 to 7 | |
n | 100 | 97 | 197 | |
MISS-21 item 7 | ||||
Baseline | ||||
Mean (SD) | 6.3 (1.2) | 6.3 (1.0) | 6.3 (1.1) | 0.745 |
Median | 7 | 7 | 7 | |
Q1 & Q3 | 6 to 7 | 6 to 7 | 6 to 7 | |
n | 132 | 133 | 265 | |
2nd questionnaire | ||||
Mean (SD) | 6.4 (1.0) | 6.3 (1.1) | 6.4 (1.0) | 0.484 |
Median | 7 | 7 | 7 | |
Q1 & Q3 | 6 to 7 | 6 to 7 | 6 to 7 | |
n | 126 | 130 | 256 | |
4 months | ||||
Mean (SD) | 6.4 (1.1) | 6.2 (1.1) | 6.3 (1.1) | 0.441 |
Median | 7 | 7 | 7 | |
Q1 & Q3 | 6 to 7 | 6 to 7 | 6 to 7 | |
n | 100 | 96 | 196 | |
MISS-21 item 8 | ||||
Baseline | ||||
Mean (SD) | 6.2 (1.2) | 6.4 (1.0) | 6.3 (1.1) | 0.154 |
Median | 7 | 7 | 7 | |
Q1 & Q3 | 6 to 7 | 6 to 7 | 6 to 7 | |
n | 132 | 133 | 265 | |
2nd questionnaire | ||||
Mean (SD) | 6.5 (0.8) | 6.3 (1.1) | 6.4 (1.0) | 0.096 |
Median | 7 | 7 | 7 | |
Q1 & Q3 | 6 to 7 | 6 to 7 | 6 to 7 | |
n | 127 | 129 | 256 | |
4 months | ||||
Mean (SD) | 6.3 (1.3) | 6.3 (1.0) | 6.3 (1.2) | 0.865 |
Median | 7 | 7 | 7 | |
Q1 & Q3 | 6 to 7 | 6 to 7 | 6 to 7 | |
n | 100 | 97 | 197 | |
MISS-21 item 9 | ||||
Baseline | ||||
Mean (SD) | 1.4 (1.3) | 1.2 (0.7) | 1.3 (1.1) | 0.034 |
Median | 1 | 1 | 1 | |
Q1 & Q3 | 1 to 1 | 1 to 1 | 1 to 1 | |
n | 132 | 133 | 265 | |
2nd questionnaire | ||||
Mean (SD) | 1.3 (1.0) | 1.2 (0.5) | 1.2 (0.8) | 0.244 |
Median | 1 | 1 | 1 | |
Q1 & Q3 | 1 to 1 | 1 to 1 | 1 to 1 | |
n | 127 | 129 | 256 | |
4 months | ||||
Mean (SD) | 1.4 (1.2) | 1.2 (0.7) | 1.3 (1.0) | 0.103 |
Median | 1 | 1 | 1 | |
Q1 & Q3 | 1 to 1 | 1 to 1 | 1 to 1 | |
n | 100 | 97 | 197 | |
MISS-21 item 10 | ||||
Baseline | ||||
Mean (SD) | 6.1 (1.4) | 6.0 (1.4) | 6.0 (1.4) | 0.506 |
Median | 7 | 6 | 7 | |
Q1 & Q3 | 6 to 7 | 6 to 7 | 6 to 7 | |
n | 131 | 133 | 264 | |
2nd questionnaire | ||||
Mean (SD) | 6.1 (1.4) | 5.9 (1.5) | 6.0 (1.5) | 0.187 |
Median | 7 | 6 | 7 | |
Q1 & Q3 | 6 to 7 | 5 to 7 | 6 to 7 | |
n | 126 | 129 | 255 | |
4 months | ||||
Mean (SD) | 6.0 (1.6) | 5.8 (1.5) | 5.9 (1.5) | 0.474 |
Median | 7 | 6 | 6 | |
Q1 & Q3 | 6 to 7 | 5 to 7 | 5 to 7 | |
n | 98 | 96 | 194 | |
MISS-21 item 11 | ||||
Baseline | ||||
Mean (SD) | 6.3 (1.2) | 6.3 (1.1) | 6.3 (1.2) | 0.927 |
Median | 7 | 7 | 7 | |
Q1 & Q3 | 6 to 7 | 6 to 7 | 6 to 7 | |
n | 131 | 132 | 263 | |
2nd questionnaire | ||||
Mean (SD) | 6.4 (1.1) | 6.2 (1.2) | 6.3 (1.1) | 0.257 |
Median | 7 | 7 | 7 | |
Q1 & Q3 | 6 to 7 | 6 to 7 | 6 to 7 | |
n | 127 | 130 | 257 | |
4 months | ||||
Mean (SD) | 6.1 (1.5) | 6.1 (1.3) | 6.1 (1.4) | 0.933 |
Median | 7 | 7 | 7 | |
Q1 & Q3 | 6 to 7 | 6 to 7 | 6 to 7 | |
n | 100 | 94 | 194 | |
MISS-21 item 12 | ||||
Baseline | ||||
Mean (SD) | 6.1 (1.2) | 6.2 (0.9) | 6.2 (1.1) | 0.613 |
Median | 6 | 6 | 6 | |
Q1 & Q3 | 6 to 7 | 6 to 7 | 6 to 7 | |
n | 131 | 133 | 264 | |
2nd questionnaire | ||||
Mean (SD) | 6.3 (1.0) | 6.1 (1.2) | 6.2 (1.1) | 0.046 |
Median | 7 | 6 | 7 | |
Q1 & Q3 | 6 to 7 | 6 to 7 | 6 to 7 | |
n | 127 | 128 | 255 | |
4 months | ||||
Mean (SD) | 6.0 (1.5) | 6.0 (1.2) | 6.0 (1.4) | 0.757 |
Median | 7 | 6 | 6 | |
Q1 & Q3 | 6 to 7 | 6 to 7 | 6 to 7 | |
n | 100 | 97 | 197 | |
MISS-21 item 13 | ||||
Baseline | ||||
Mean (SD) | 1.9 (1.9) | 1.9 (1.7) | 1.9 (1.8) | 0.874 |
Median | 1 | 1 | 1 | |
Q1 & Q3 | 1 to 2 | 1 to 2 | 1 to 2 | |
n | 129 | 133 | 262 | |
2nd questionnaire | ||||
Mean (SD) | 2.2 (2.1) | 1.9 (1.7) | 2.0 (1.9) | 0.338 |
Median | 1 | 1 | 1 | |
Q1 & Q3 | 1 to 2 | 1 to 2 | 1 to 2 | |
n | 127 | 129 | 256 | |
4 months | ||||
Mean (SD) | 2.1 (1.9) | 2.0 (1.9) | 2.0 (1.9) | 0.738 |
Median | 1 | 1 | 1 | |
Q1 & Q3 | 1 to 2 | 1 to 2 | 1 to 2 | |
n | 101 | 97 | 198 | |
MISS-21 item 14 | ||||
Baseline | ||||
Mean (SD) | 1.4 (1.2) | 1.3 (1.1) | 1.4 (1.2) | 0.927 |
Median | 1 | 1 | 1 | |
Q1 & Q3 | 1 to 1 | 1 to 1 | 1 to 1 | |
n | 128 | 130 | 258 | |
2nd questionnaire | ||||
Mean (SD) | 1.3 (1.2) | 1.4 (1.2) | 1.4 (1.2) | 0.641 |
Median | 1 | 1 | 1 | |
Q1 & Q3 | 1 to 1 | 1 to 1 | 1 to 1 | |
n | 122 | 128 | 250 | |
4 months | ||||
Mean (SD) | 1.5 (1.3) | 1.5 (1.2) | 1.5 (1.3) | 0.934 |
Median | 1 | 1 | 1 | |
Q1 & Q3 | 1 to 1 | 1 to 1 | 1 to 1 | |
n | 98 | 97 | 195 | |
MISS-21 item 15 | ||||
Baseline | ||||
Mean (SD) | 6.1 (1.3) | 6.2 (1.1) | 6.1 (1.2) | 0.411 |
Median | 7 | 7 | 7 | |
Q1 & Q3 | 6 to 7 | 6 to 7 | 6 to 7 | |
n | 128 | 134 | 262 | |
2nd questionnaire | ||||
Mean (SD) | 6.3 (1.1) | 6.2 (1.3) | 6.3 (1.2) | 0.359 |
Median | 7 | 7 | 7 | |
Q1 & Q3 | 6 to 7 | 6 to 7 | 6 to 7 | |
n | 125 | 131 | 256 | |
4 months | ||||
Mean (SD) | 6.2 (1.4) | 6.2 (1.1) | 6.2 (1.2) | 0.998 |
Median | 7 | 7 | 7 | |
Q1 & Q3 | 6 to 7 | 6 to 7 | 6 to 7 | |
n | 100 | 96 | 196 | |
MISS-21 item 16 | ||||
Baseline | ||||
Mean (SD) | 6.4 (0.9) | 6.5 (0.9) | 6.4 (0.9) | 0.652 |
Median | 7 | 7 | 7 | |
Q1 & Q3 | 6 to 7 | 6 to 7 | 6 to 7 | |
n | 128 | 133 | 261 | |
2nd questionnaire | ||||
Mean (SD) | 6.6 (0.9) | 6.4 (1.1) | 6.5 (1.0) | 0.139 |
Median | 7 | 7 | 7 | |
Q1 & Q3 | 6 to 7 | 6 to 7 | 6 to 7 | |
n | 125 | 131 | 256 | |
4 months | ||||
Mean (SD) | 6.4 (1.1) | 6.3 (1.0) | 6.4 (1.1) | 0.746 |
Median | 7 | 7 | 7 | |
Q1 & Q3 | 6 to 7 | 6 to 7 | 6 to 7 | |
n | 100 | 97 | 197 | |
MISS-21 item 17 | ||||
Baseline | ||||
Mean (SD) | 5.1 (1.7) | 5.2 (1.6) | 5.2 (1.6) | 0.524 |
Median | 5 | 6 | 5 | |
Q1 & Q3 | 4 to 7 | 4 to 7 | 4 to 7 | |
n | 127 | 128 | 255 | |
2nd questionnaire | ||||
Mean (SD) | 5.4 (1.7) | 5.3 (1.5) | 5.3 (1.6) | 0.760 |
Median | 6 | 6 | 6 | |
Q1 & Q3 | 5 to 7 | 4 to 7 | 4 to 7 | |
n | 118 | 126 | 244 | |
4 months | ||||
Mean (SD) | 5.2 (1.8) | 5.1 (1.6) | 5.2 (1.7) | 0.536 |
Median | 6 | 5 | 6 | |
Q1 & Q3 | 4 to 7 | 4 to 6 | 4 to 7 | |
n | 97 | 94 | 191 | |
MISS-21 item 18 | ||||
Baseline | ||||
Mean (SD) | 5.9 (1.3) | 6.0 (1.2) | 5.9 (1.2) | 0.453 |
Median | 6 | 6 | 6 | |
Q1 & Q3 | 5 to 7 | 6 to 7 | 5 to 7 | |
n | 129 | 129 | 258 | |
2nd questionnaire | ||||
Mean (SD) | 6.0 (1.3) | 5.9 (1.3) | 6.0 (1.3) | 0.328 |
Median | 6 | 6 | 6 | |
Q1 & Q3 | 6 to 7 | 5 to 7 | 5.5 to 7 | |
n | 125 | 126 | 251 | |
4 months | ||||
Mean (SD) | 5.8 (1.4) | 5.7 (1.3) | 5.8 (1.4) | 0.748 |
Median | 6 | 6 | 6 | |
Q1 & Q3 | 5 to 7 | 5 to 7 | 5 to 7 | |
n | 100 | 95 | 195 | |
MISS-21 item 19 | ||||
Baseline | ||||
Mean (SD) | 6.1 (1.2) | 6.3 (1.0) | 6.2 (1.1) | 0.264 |
Median | 7 | 7 | 7 | |
Q1 & Q3 | 6 to 7 | 6 to 7 | 6 to 7 | |
n | 125 | 129 | 254 | |
2nd questionnaire | ||||
Mean (SD) | 6.2 (1.2) | 6.0 (1.3) | 6.1 (1.3) | 0.258 |
Median | 7 | 6 | 7 | |
Q1 & Q3 | 6 to 7 | 6 to 7 | 6 to 7 | |
n | 123 | 128 | 251 | |
4 months | ||||
Mean (SD) | 6.0 (1.4) | 5.8 (1.3) | 5.9 (1.3) | 0.463 |
Median | 7 | 6 | 6 | |
Q1 & Q3 | 5 to 7 | 5 to 7 | 5 to 7 | |
n | 100 | 93 | 193 | |
MISS-21 item 20 | ||||
Baseline | ||||
Mean (SD) | 2.1 (1.7) | 1.7 (1.3) | 1.9 (1.5) | 0.035 |
Median | 1 | 1 | 1 | |
Q1 & Q3 | 1 to 2 | 1 to 2 | 1 to 2 | |
n | 127 | 130 | 257 | |
2nd questionnaire | ||||
Mean (SD) | 2.0 (1.7) | 2.0 (1.5) | 2.0 (1.6) | 0.935 |
Median | 1 | 1 | 1 | |
Q1 & Q3 | 1 to 2 | 1 to 2 | 1 to 2 | |
n | 122 | 127 | 249 | |
4 months | ||||
Mean (SD) | 2.0 (1.6) | 2.1 (1.7) | 2.1 (1.6) | 0.715 |
Median | 1 | 1 | 1 | |
Q1 & Q3 | 1 to 2 | 1 to 2.5 | 1 to 2 | |
n | 99 | 95 | 194 | |
MISS-21 item 21 | ||||
Baseline | ||||
Mean (SD) | 1.8 (1.5) | 1.8 (1.5) | 1.8 (1.5) | 0.824 |
Median | 1 | 1 | 1 | |
Q1 & Q3 | 1 to 2 | 1 to 2 | 1 to 2 | |
n | 129 | 127 | 256 | |
2nd questionnaire | ||||
Mean (SD) | 2.0 (1.8) | 1.8 (1.4) | 1.9 (1.6) | 0.330 |
Median | 1 | 1 | 1 | |
Q1 & Q3 | 1 to 2 | 1 to 2 | 1 to 2 | |
n | 122 | 126 | 248 | |
4 months | ||||
Mean (SD) | 2.0 (1.6) | 1.7 (1.4) | 1.8 (1.5) | 0.272 |
Median | 1 | 1 | 1 | |
Q1 & Q3 | 1 to 2 | 1 to 2 | 1 to 2 | |
n | 98 | 96 | 194 | |