Journal of Patient-Reported Outcomes

Table 4 Responsiveness in ThyPRO score after 4 months of treatment

From: Psychometric properties of the thyroid-specific quality of life questionnaire ThyPRO in Singaporean patients with Graves’ disease

Scale	ThyPRO
	Baseline		At 4 months		Cohen’s Effect size
	Mean	SD	Mean	SD	Cohen’s Effect size
Goitre Symptoms	11.8	12.0	9.72	9.97	0.2^a
Hyperthyroid Symptoms	36.8	25.5	19.2	20.2	0.8 ^b
Hypothyroid Symptoms	26.7	24.4	23.2	21.6	0.2^a
Eye Symptoms	13.4	16.4	14.2	13.8	−0.1
Tiredness	49.4	25.2	42.8	22.2	0.3^a
Cognitive Complaints	24.9	29.7	18.8	23.0	0.2^a
Anxiety	29.9	24.8	21.2	19.6	0.4^a
Depressivity	27.6	24.6	23.5	15.7	0.2^a
Emotional Susceptibility	34.5	23.3	27.5	17.5	0.3^a
Impact on Social Life	18.8	22.4	11.6	17.9	0.4^a
Impact on Daily Life	21.1	25.7	14.1	17.6	0.3^a
Impact on Sex Life	18.9	30.7	11.4	21.5	0.3^a
Cosmetic Complaints	19.9	25.0	17.4	20.7	0.1
Overall QOL, Impact	31.3	32.9	23.6	31.6	0.3^a

Cohen’s Effect Size: 0.2 to 0.5 signifies small effect size^a; 0.5 to 0.8 signifies moderate effect size^b; above 0.8 signifies large effect size® Annotation based on rounded up to 1 decimal place
Thyroid experts anticipated the scales in shades to change with treatment

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