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Table 4 Responsiveness in ThyPRO score after 4 months of treatment

From: Psychometric properties of the thyroid-specific quality of life questionnaire ThyPRO in Singaporean patients with Graves’ disease

Scale ThyPRO
Baseline At 4 months Cohen’s Effect size
Mean SD Mean SD
Goitre Symptoms 11.8 12.0 9.72 9.97 0.2a
Hyperthyroid Symptoms 36.8 25.5 19.2 20.2 0.8 b
Hypothyroid Symptoms 26.7 24.4 23.2 21.6 0.2a
Eye Symptoms 13.4 16.4 14.2 13.8 −0.1
Tiredness 49.4 25.2 42.8 22.2 0.3a
Cognitive Complaints 24.9 29.7 18.8 23.0 0.2a
Anxiety 29.9 24.8 21.2 19.6 0.4a
Depressivity 27.6 24.6 23.5 15.7 0.2a
Emotional Susceptibility 34.5 23.3 27.5 17.5 0.3a
Impact on Social Life 18.8 22.4 11.6 17.9 0.4a
Impact on Daily Life 21.1 25.7 14.1 17.6 0.3a
Impact on Sex Life 18.9 30.7 11.4 21.5 0.3a
Cosmetic Complaints 19.9 25.0 17.4 20.7 0.1
Overall QOL, Impact 31.3 32.9 23.6 31.6 0.3a
  1. Cohen’s Effect Size: 0.2 to 0.5 signifies small effect sizea; 0.5 to 0.8 signifies moderate effect sizeb; above 0.8 signifies large effect size® Annotation based on rounded up to 1 decimal place
  2. Thyroid experts anticipated the scales in shades to change with treatment