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Table 4 Mean FACIT-Fatigue scores across various criterion measures (pooled population)

From: Psychometric properties of FACIT-Fatigue in systemic lupus erythematosus: a pooled analysis of three phase 3 randomised, double-blind, parallel-group controlled studies (BLISS-SC, BLISS-52, BLISS-76)

Week Patients, n Category Mean [95% CI] F-value p-valuea
  SELENA-SLEDAI
0 2489 < 6 33.8 [31.8, 35.9] 6.0 0.0025*
6–9 31.0 [30.3, 31.8]
≥10 30.2 [29.6, 30.8]
24 2313 < 6 37.2 [36.6, 37.9] 23.8 < 0.0001**
6–9 34.7 [33.9, 35.5]
≥10 33.1 [32.0, 34.2]
52 1990 < 6 37.6 [37.0, 38.3] 33.2 < 0.0001**
6–9 34.4 [33.6, 35.3]
≥10 32.0 [30.5, 33.4]
  PGA
0 2489 None/mild 33.8 [32.5, 35.2] 24.1 < 0.0001**
Moderate 31.0 [30.4, 31.5]
Severe 27.8 [26.6, 28.9]
24 2313 None/mild 38.1 [37.5, 38.8] 78.2 < 0.0001**
Moderate 33.4 [32.8, 34.1]
Severe 26.4 [23.9, 28.8]
52 1990 None/mild 37.9 [37.3, 38.5] 64.8 < 0.0001**
Moderate 32.8 [32.0, 33.7]
Severe 26.3 [23.2, 29.4]
  BILAG General A/B
0 2489 No 31.6 [31.1, 32.1] 132.8 < 0.0001
Yes 22.7 [21.3, 24.1]
24 2313 No 36.0 [35.6, 36.5] 90.6 < 0.0001
Yes 24.3 [22.0, 26.7]
52 1990 No 36.2 [35.7, 36.7] 63.0 < 0.0001
Yes 23.6 [20.6, 26.7]
  BILAG Musculoskeletal A/B
0 2489 No 34.0 [33.2, 34.8] 108.2 < 0.0001
Yes 28.9 [28.4, 29.5]
24 2313 No 37.2 [36.7, 37.8] 175.5 < 0.0001
Yes 30.0 [29.0, 30.9]
52 1990 No 37.5 [36.9, 38.0] 162.8 < 0.0001
Yes 29.7 [28.6, 30.7]
  1. ap-value testing: H0: μi = μj, for all i,j
  2. *p < 0.05 for < 6 versus 6–9 (2.9; 95% CI: [0.7, 5.2]) or ≥ 10 (3.8; 95% CI: [1.6, 5.9]); **p < 0.05 for all pairwise comparisons
  3. Spearman rank-order correlations were used to assess the relationship between changes in FACIT-Fatigue and the SELENA-SLEDAI and PGA
  4. BILAG British Isles Lupus Assessment Group, CI confidence interval, FACIT Functional Assessment of Chronic Illness Therapy, PGA Physician’s Global Assessment, SELENA-SLEDAI Safety of Estrogens in Lupus Erythematosus National Assessment-Systemic Lupus Erythematosus Disease Activity Index