Estimating health state utilities in hemophagocytic lymphohistiocytosis

Journal of Patient-Reported Outcomes

Table 3 Estimated utilities or preference weights from TTO and VAS assessments of the HLH states

Health state Descriptions	TTO Utility value	95% Confidence Limits		P-value versus active HLH disease
Active HLH	0.32	0.24	0.39	reference
Active HLH on chemotherapy	0.26	0.17	0.34	0.05
Active HLH with CNS involvement	0.27	0.18	0.35	0.09
Undergoing HSCT	0.18	0.07	0.28	0.00
Graft versus Host disease	0.07	−0.04	0.17	<.0001
Transplant Success	0.72	0.67	0.77	<.0001
End of life	−0.17	− 0.27	− 0.07	<.0001
Health state Descriptions	VAS value	95% Confidence Limits		P-value versus active HLH disease
Active HLH	31	27	34	reference
Active HLH on chemotherapy	28	25	32	0.093
Active HLH with CNS involvement	27	24	31	0.009
Undergoing HSCT	23	20	26	<.0001
Graft versus Host disease	21	18	23	<.0001
Transplant Success	55	52	59	<.0001
End of life	23	20	26	<.0001