|Criteria defining moderate exacerbations ||Criteria defining severe exacerbations |
1 or more of the following criteria and must also result in a temporary change in treatment:|
● Nocturnal awakening(s) due to asthma requiring SABA use for at least 2 consecutive nights or an increase of at least 0.75 points in daily symptom score from baseline value on at least 2 consecutive days;
● An increase from baseline in SABA use on at least 2 consecutive days (a minimum increase of 4 puffs per day);
● A 20% or more decrease in peak expiratory flow from baseline on at least 2 consecutive mornings or evenings or a 20% or more decrease in FEV1 from baseline;
● A visit to the emergency department or an unscheduled visit to the trial site for asthma treatment not requiring systemic corticosteroids.
1 or more of the following criteria:|
● A requirement for systemic corticosteroids for the treatment of asthma symptoms for at least 3 days;
● An emergency department visit due to asthma requiring systemic corticosteroids, or a hospitalization for more than 12 h due to asthma.