Table 2 Demographic and disease characteristics of study sample
From: Patient-reported burden of hereditary transthyretin amyloidosis on functioning and well-being
Patients with hATTR Amyloidosis (N = 14) | |
Mean (SD) [Range] | |
Age (years) | 61.5 (14.5) [20–76] |
Age at First hATTR Amyloidosis Symptom (years) | 50.36 (15.13) [14–73] |
Age at Diagnosis (years) | 56.29 (16.55) [17–75] |
Time Since Diagnosis (years) | 5.21 (5.63) [1–21] |
N (%) | |
Sex | |
Male | 8 (57%) |
Female | 6 (43%) |
Race | |
Caucasian/white | 13 (93%) |
Asian | 1 (7%) |
Education | |
High school | 1 (7%) |
Some college but no degree | 1 (7%) |
Associate’s degree or technical certificate | 1 (7%) |
Bachelor’s degree | 7 (50%) |
Graduate degree | 4 (29%) |
Marital Status | |
Married | 10 (71%) |
Divorced | 3 (21%) |
Never married | 1 (7%) |
Region of Residence | |
Northeast US | 5 (36%) |
South US | 5 (36%) |
West US | 2 (14%) |
Midwest US | 1 (7%) |
Canada | 1 (7%) |
hATTR Amyloidosis Type | |
hATTR amyloidosis with symptoms of both PN and CM | 8 (57%) |
hATTR amyloidosis with symptoms of PN only | 6 (43%) |
Genetic Variant of hATTR Amyloidosis | |
V30M | 5 (36%) |
T60A | 3 (21%) |
Othera | 4 (29%) |
Unsure | 2 (14%) |
Age at Symptom Onset | |
Early onset (< 50 years of age) | 7 (50%) |
Late onset (≥50 years of age) | 7 (50%) |
Stage of Ambulatory Disability | |
Stage 1: Able to walk unassisted | 8 (57%) |
Stage 2: Requires assistance with walking (e.g., walker, cane) | 3 (21%) |
Stage 3: Unable to walk (e.g., wheelchair, scooter) | 3 (21%) |
Impacted Organs/Systemsb | |
Nervous | 14 (100%) |
Cardiac | 8 (57%) |
Gastrointestinal | 8 (57%) |
Ocular | 4 (29%) |