Table 2 List of Domains and Measures Considered for the Linking

Anxiety

NRS: During the past week, including today, how would you describe your level of anxiety, on the average?

Emotional Distress-Anxiety 8a

.70

Yes

PRO-CTCAE: In the past 7 days, what was the severity of your anxiety at its worst?

.75

Yes

PRO-CTCAE: In the past 7 days, how often did you feel anxiety?

.77

No

Difference in smd’s by age > 0.1^b

PRO-CTCAE: In the past 7 days, how much did anxiety interfere with your usual or daily activities?

.74

No

Difference in smd’s by age > 0.1

Depression

NRS: During the past week, including today, how would you describe your level of depression, on the average?

Emotional Distress-Depression 8a

.78

Yes

PRO-CTCAE: In the past 7 days, how often did you feel that nothing could cheer you up?

.78

Yes

PRO-CTCAE: In the past 7 days, what was the severity of your feelings that nothing could cheer you up at the worst?

.79

Yes

PRO-CTCAE: In the past 7 days, how much did feeling that nothing could cheer you up interfere with your usual or daily activities?

.75

Yes

PRO-CTCAE: In the past 7 days, how often did you have sad or unhappy feelings?

.74

Yes

PRO-CTCAE: In the past 7 days, what was the severity of your sad/unhappy feelings at their worst?

.72

Yes

PRO-CTCAE: In the past 7 days, how much did sad or unhappy feelings interfere you’re your usual or daily activities?

.76

Yes

Fatigue

NRS: During the past week, including today, how would you describe your level of fatigue on average?

Fatigue custom form (7a + 2)

.76

Yes

PRO-CTCAE: In the past 7 days, what was severity of your fatigue, tiredness, or lack of energy at its worst?

.76

Yes

PRO-CTCAE: In the past 7 days, how much did fatigue, tiredness, or lack of energy interfere with your usual or daily activities?

.82

Yes

Sleep

NRS: During the past week, including today, how would you describe the quality of your sleep on average?

Sleep Disturbance 8a

.85

Yes

PRO-CTCAE: In the past 7 days, what was the severity of your insomnia including difficulty falling asleep, staying asleep, or waking up early at its worst?

.84

Yes

PRO-CTCAE: In the past 7 days, how much did insomnia including difficulty falling asleep, staying asleep, or waking up early interfere with your usual or daily activities?

.79

Yes

Pain Intensity

NRS: During the past week, including today, how would you describe the severity of your pain on average?

Pain Intensity 3a

.87

Yes

PRO-CTCAE: In the past 7 days, what was severity of your pain at its worst?

.89

Yes

Pain Interference

PRO-CTCAE: In the past 7 days, how much did pain interfere with your usual or daily activities?

Pain Interference custom form (8a-1)

.88

Yes

Social function

NRS: During the past week, including today, how would you describe your level of social activity?

.65

No

Low correlation

Physical function

NRS: During the past week, including today, how would you describe your overall physical well being?

.53

No

Low correlation

Global mental health

NRS: During the past 7 days, including today, how would you describe your overall quality of life?

.57

No

Low correlation

NRS: During the past week, including today, how would you describe your overall emotional well-being?

.64

No

Low correlation

NRS: During the past week, including today, how would you describe your overall mental (intellectual) well-being?

.59

No

Low correlation