Impact of comorbidities and treatment burden on general well-being among women’s cancer survivors

Anderson, R. T.; Eton, D. T.; Camacho, F. T.; Kennedy, E. M.; Brenin, C. M.; DeGuzman, P. B.; Carter, K. F.; Guterbock, T.; Ruddy, K. J.; Cohn, W. F.

doi:10.1186/s41687-020-00264-z

Journal of Patient-Reported Outcomes

Table 4 Predictors of impact and general health status

From: Impact of comorbidities and treatment burden on general well-being among women’s cancer survivors

Unadjusted predictors	Description	Effect measure^b	Global physical health (GPH)		Global mental health (GMH)		Impact score
Unadjusted predictors	Description	Effect measure^b	Effect estimate^a	Effect size (ω²)	Effect estimate^a	Effect size(ω²)	Effect estimate^a	Effect size(ω²)
Age (categorical)	29–55,56-63,64-71,72+	\|∆_max\|	3.44	0.00	1.13	0.00	7.37	0.00
Age (continuous)	29–89	β	− 0.04	0.00	0.01	0.00	−0.16	0.00
Race	White vs Others	β	5.54*	0.02	5.49*	0.02	−9.66	0.01
Rurality	Urban Residence vs Rural	β	1.01	0.00	0.86	0.00	0.74	0.00
Adjusted Predictors^c				ω²_partial		ω²_partial		ω²_partial
Education (categorical)	< HS (l), HS-college, Graduate (h)	\|∆_max,adj\|	10.82**	0.05	7.52*	0.03	5.51	0.00
Education (ordinal)	1,2,3	β_adj	4.12**	0.04	3.49**	0.03	−2.35	0.01
Marital status	Married vs Others	β_adj	3.17	0.01	4.05*	0.03	−7.38	0.02
Employment (categorical)	Disabled (l), < Full Time, Full Time (h)	\|∆_max,adj\|	7.63	0.01	5.30	0.02	26.20**	0.05
Income (categorical, non-missing)	0-35 K(l),35-75 K,75 + K (h)	\|∆_max,adj\|	6.97*	0.03	6.78*	0.03	4.51	-0.01^d
Income (ordinal, non-missing)	1,2,3	β_adj	3.42*	0.03	3.39*	0.03	− 2.28	0.00
Financial security	Comfortable vs Not comfortable	β_adj	6.55***	0.06	9.71***	0.15	−18.0***	0.10
Health literacy	No help needed vs Help needed	β_adj	1.81	0.00	3.36	0.01	−8.61*	0.02
No. of prior comorbidities (ordinal)	0,1,2,3+	β _adj	−3.59***	0.15	−2.35***	0.08	4.17**	0.04
Cancer type (categorical)	Other (l), Endometrial, Breast (h)	\|∆_max\|	4.01	0.01	2.90	0.00	2.84	-0.01^d
Cancer treatment (categorical)	S, RS, CS, RCS, other	\|∆_max,adj\|	2.45	−0.01⁸	3.76	0.00	10.48	0.01
Chemotherapy	Yes vs No	β _adj	−1.25	0.00	−2.70	0.01	4.87	0.00
Self-management difficulty score (continuous, non-missing)	1 = Lowest – 5 = Highest	β _adj	−0.88	0.00	−1.51	0.01	11.75***	0.13
Impact Score (continuous)	0 = Lowest – 100 = Highest	β _adj	−0.25***	0.28	−0.22***	0.23	n/a	n/a

^a * p < .05, ** p < .01, *** p < .001
^b|∆_max| = maximum mean difference, β, β _adj = mean (adjusted) difference using regression weights
^cEstimates were adjusted by differing sets of antecedent covariates chosen a priori for each predictor based on salience and non-overlap from the following list: age, race, rurality, education, marital status employment, income financial security, health literacy, number of comorbidities, cancer type, chemotherapy, challenge, and impact (Please see Appendix B for the specific predictor-covariate sets)
^d Although the population parameter \( \hat{\omega^2} \)estimates is always positive, the estimate can be negative in situations where predictive power is weak

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