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Table 2 QOL Scores by Maximum Grade Adverse Event Per Week

From: Patient-reported quality-of-life outcomes in relation to provider-assessed adverse events during head and neck radiotherapy

   Grade 0 Grade 1 Grade 2 Grade 3     Grade 0 Grade 1 Grade 2 Grade 3  
  Week Mean
(SD)
Mean (SD) Mean (SD) Mean (SD) P-value   Week Mean (SD) Mean (SD) Mean (SD) Mean (SD) P-value
Overall QOL 0 78.8 (20.0) 75.7 (16.3) 61.4 (24.1)   0.15 Pain Frequency 0 84.0 (18.7) 74.3 (23.8) 52.9 (39.9)   0.09
1 81.7 (20.4) 74.6 (24.1) 64.5 (20.1)   0.03   1 72.4 (34.0) 75.8 (28.3) 74.0 (23.5)   0.81
3   79.3 (16.7) 64.7 (21.4) 68.0 (32.7) 0.09   3   78.0 (21.1) 65.0 (23.0) 74.0 (20.7) 0.15
5   63.3 (15.3) 65.2 (21.4) 60.7 (22.8) 0.72   5   50.0 (28.3) 64.1 (24.2) 61.9 (25.9) 0.69
7    62.1 (20.0) 77.5 (20.6) 0.16   7    65.7 (26.5) 55.0 (26.5) 0.35
Mental WB 0 80.6 (20.3) 80.5 (14.7) 71.4 (21.2)   0.43 Pain Severity 0 86.3 (15.0) 78.6 (17.7) 68.6 (34.4)   0.22
1 81.7 (20.9) 79.2 (17.4) 66.0 (19.0)   0.02   1 86.3 (17.5) 77.9 (24.8) 77.0 (22.0)   0.32
3   78.7 (16.4) 73.7 (18.9) 78.0 (29.5) 0.49   3   80.0 (15.1) 67.9 (21.3) 66.0 (28.8) 0.20
5   63.3 (5.8) 71.2 (22.0) 68.1 (23.4) 0.57   5   60.0 (28.3) 71.0 (21.0) 68.8 (20.9) 0.67
7    69.4 (18.8) 85.0 (12.9) 0.10   7    69.4 (23.2) 60.0 (18.3) 0.34
Physical WB 0 69.4 (19.1) 70.5 (17.2) 48.6 (19.5)   0.04 Fatigue 0 66.0 (27.1) 55.7 (26.9) 52.9 (27.5)   0.22
1 71.1 (24.7) 71.3 (23.3) 56.0 (17.9)   0.03   1 60.6 (25.3) 59.2 (26.2) 42.5 (17.4)   0.08
3   70.7 (17.5) 63.7 (20.5) 62.0 (25.9) 0.58   3   57.3 (27.9) 50.3 (25.8) 60.0 (15.8) 0.50
5   60.0 (20.0) 61.5 (21.9) 54.4 (25.8) 0.62   5   33.3 (11.5) 49.8 (24.2) 50.6 (18.4) 0.36
7    57.9 (19.7) 72.5 (17.1) 0.16   7    44.7 (23.3) 60.0 (34.6) 0.48
Emotional WB 0 75.6 (20.8) 72.9 (17.1) 58.6 (23.4)   0.15 Level of Support 0 94.3 (11.4) 94.3 (12.1) 85.7 (29.9)   0.94
1 77.2 (22.7) 72.9 (21.8) 67.0 (20.3)   0.22   1 93.9 (16.1) 94.6 (7.8) 90.5 (15.4)   0.31
3   78.7 (13.0) 70.3 (22.1) 76.0 (33.6) 0.44   3   95.0 (8.5) 94.5 (10.3) 94.0 (13.4) 0.93
5   66.7 (11.5) 65.0 (21.6) 66.3 (24.7) 0.94   5   100.0 (0.0) 91.2 (15.0) 89.4 (15.3) 0.30
7    68.1 (19.9) 77.5 (20.6) 0.34   7    93.5 (11.4) 96.7 (5.8) 0.74
Social Activity 0 71.2 (25.9) 67.5 (20.5) 48.6 (38.0)   0.23 Financial Concerns 0 64.9 (31.9) 63.8 (35.1) 82.9 (37.3)   0.21
1 63.9 (31.5) 65.0 (27.0) 55.5 (21.9)   0.41   1 67.2 (33.7) 66.7 (30.3) 75.5 (26.8)   0.68
3   71.3 (21.0) 54.5 (25.9) 56.0 (31.3) 0.11   3   64.7 (34.2) 70.0 (31.5) 76.0 (37.8) 0.69
5   66.7 (25.2) 54.5 (25.9) 46.3 (27.5) 0.40   5   93.3 (11.5) 69.8 (32.2) 58.1 (32.3) 0.10
7    54.5 (23.0) 62.5 (33.0) 0.51   7    75.7 (26.1) 60.0 (52.9) 0.72
Spiritual WB 0 81.5 (20.9) 78.0 (17.9) 70.0 (26.8)   0.42 Legal Concerns 0 74.6 (34.0) 72.4 (33.2) 97.1 (7.6)   0.07
1 82.8 (17.4) 77.1 (25.6) 74.7 (25.0)   0.82   1 84.4 (25.0) 77.1 (35.1) 78.0 (32.5)   0.77
3   78.0 (17.4) 76.5 (20.7) 75.0 (37.9) 0.89   3   66.0 (37.0) 82.9 (28.2) 90.0 (22.4) 0.07
5   90.0 (10.0) 75.3 (21.7) 72.0 (26.8) 0.49   5   86.7 (23.1) 78.8 (31.3) 69.4 (34.7) 0.52
7    76.7 (20.9) 85.0 (19.1) 0.40   7    76.9 (32.1) 47.5 (37.7) 0.15
  1. Analyzed using Kruskal-Wallis methodology
  2. The only patient with grade 3 adverse event at week 1 was excluded
  3. The only two patients with grade 4 adverse events were excluded