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Table 3 Known-Groups Validity: PROMIS-PF and Worst Stiffness NRS

From: Psychometric properties of a custom Patient-Reported Outcomes Measurement Information System (PROMIS) physical function short form and worst stiffness numeric rating scale in tenosynovial giant cell tumors

   Pain Levela Overall
F-value
(P-value)
P-valueb
  Mild 1–4.9 Moderate 5–6.9 Severe > 7
Missing N N LS mean (SE) N LS mean (SE) N LS mean (SE)
PROMIS Physical Functioning
 All Tumors 10 39 39.85 (1.44) 41 36.64 (1.51) 30 33.74 (1.51) 3.87 (0.0002) 1: 0.0218 / 2:< 0.0001 / 3: 0.0750
 Knee Tumors 7 26 39.27 (1.69) 22 36.44 (1.86) 18 33.54 (1.67) 2.39 (0.0196) 1: 0.1669 / 2: 0.0025 / 3: 0.2480
 Other (Non-Knee) Lower Extremity Tumors 3 8 45.14 (3.59) 16 42.46 (2.99) 10 38.13 (2.92) 2.51 (0.0412) 1: 0.5264 / 2: 0.0713 / 3: 0.2444
Worst Stiffness NRS
 All Tumors 8 39 4.09 (0.31) 42 6.21 (0.32) 31 7.79 (0.32) 21.96 (< 0.0001) 1:< 0.0001 / 2:< 0.0001 / 3:< 0.0001
 Knee Tumors 5 26 4.13 (0.39) 23 5.89 (0.42) 19 7.72 (0.38) 11.76 (< 0.0001) 1:< 0.0001 / 2:< 0.0001 / 3:< 0.0001
 Other (Non-Knee) Lower Extremity Tumors 3 8 3.13 (0.72) 16 5.89 (0.60) 10 7.55 (0.58) 10.67 (< 0.0001) 1:< 0.0001 / 2:< 0.0001 / 3: 0.0106
   Tumor Volume Scorea Overall
F-value
(P-value)
P-valueb
  Small < 5 Medium 5–10 Large > 10
Missing N N LS mean (SE) N LS mean (SE) N LS mean (SE)
PROMIS Physical Functioning
 All Tumors 9 41 37.11 (1.75) 33 37.28 (1.55) 37 36.64 (1.72) 1.19 (0.3047) 4: 0.9923 / 5: 0.9397 / 6: 0.9031
 Knee Tumors 6 33 36.89 (1.97) 23 35.77 (1.75) 11 36.64 (2.43) 0.87 (0.5680) 4: 0.7806 / 5: 0.9939 / 6: 0.9312
 Other (Non-Knee) Lower Extremity Tumors 3 6 36.68 (4.07) 7 40.37 (3.82) 21 39.97 (2.96) 1.35 (0.2681) 4: 0.5196 / 5: 0.5144 / 6: 0.9881
Worst Stiffness NRS
 All Tumors 10 42 5.63 (0.59) 32 5.99 (0.53) 36 6.00 (0.59) 0.53 (0.8637) 4: 0.7424 / 5: 0.7086 / 6: 0.9995
 Knee Tumors 6 34 5.93 (0.69) 23 6.32 (0.62) 10 6.00 (0.90) 0.37 (0.9558) 4: 0.7932 / 5: 0.9967 / 6: 0.9375
 Other (Non-Knee) Lower Extremity Tumors 4 6 7.55 (1.37) 6 7.14 (1.32) 21 6.87 (1.00) 0.60 (0.7472) 4: 0.9358 / 5: 0.7776 6: 0.9577
   Stiffness Levela Overall F-value
(P-value)
P-valueb
  Low 1–4.9 Medium 5–6.9 High > 7
Missing N N LS mean (SE) N LS mean (SE) N LS mean (SE)
PROMIS Physical Functioning
 All Tumors 10 34 39.77 (1.51) 48 36.48 (1.49) 28 34.03 (1.58) 3.21 (0.0013) 7: 0.0212 / 8: 0.0002 / 9: 0.1436
 Knee Tumors 7 20 38.21 (1.82) 30 36.42 (1.68) 16 33.14 (1.94) 1.73 (0.0980) 7: 0.4843 / 8: 0.0245 / 9: 0.1528
 Other (Non-Knee) Lower Extremity Tumors 3 10 47.41 (2.92) 14 40.53 (2.55) 10 39.21 (2.46) 4.66 (0.0017) 7: 0.0073 / 8: 0.0033 / 9: 0.7984
   Physical Functioning Limitation Levela Overall
F-value
(P-value)
P-valueb
  No Limitation > 45 Low 35–45 Medium 30–35 High < 30
Missing N N LS mean (SE) N LS mean (SE) N LS mean (SE) N LS mean (SE)   
Worst Stiffness NRS
 All Tumors 10 13 4.62 (0.67) 62 5.52 (0.49) 28 6.32 (0.50) 7 7.31 (0.82) 1.90 (0.0481) 10: 0.4194 11: 0.0459
12: 0.0220 13: 0.2639
14: 0.1048 15: 0.6305
 Knee Tumors 7 7 5.07 (0.89) 39 5.68 (0.63) 18 6.24 (0.59) 2 7.79 (1.45) 0.90 (0.5469) 10: 0.8758 11: 0.5640
12: 0.3940 13: 0.7772
14: 0.5292 15: 0.7645
 Other (Non-Knee) Lower Extremity Tumors 3 4 5.21 (1.13) 18 7.29 (0.84) 9 8.59 (1.10) 3 9.85 (1.50) 2.18 (0.0650) 10: 0.2141 11: 0.0363
12: 0.0369 13: 0.4281
14: 0.2414 15: 0.7354
  1. aCategories were determined based on the distribution of scores and clinical relevance
  2. bGeneral linear model (PROC GLM) controlling for age, gender, race, and BMI. LS = least squared means; SE = standard error
  3. Pairwise comparisons between LS means were performed using Scheffe’s test adjusting for multiple comparisons
  4. 1 = mild vs. moderate; 2 = mild vs. severe; 3 = moderate vs. severe; 4 = small vs. medium; 5 = small vs. large; 6 = medium vs. large; 7 = low vs. medium; 8 = low vs. high; 9 = medium vs. high; 10 = no limitation vs. low; 11 = no limitation vs. medium;12 = no limitation vs. high; 13 = low vs. medium; 14 = low vs. high; 15 = medium vs. high