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Fig. 2 | Journal of Patient-Reported Outcomes

Fig. 2

From: Patient-reported outcome instruments used in immune-checkpoint inhibitor clinical trials in oncology: a systematic review

Fig. 2

Frequency of use and combination of PRO instruments in ICI-CTs (n = 156). a Number of PRO instruments divided into categories and start year of the ICI-CTs. Green: general health status; Blue: cancer-specific; Red: disease/tumor-specific; Yellow: symptom-specific; Dark blue: items libraries/single items; Purple: other (e.g. treatment-specific). b Absolute number of instruments across all ICI-CTs divided per category. The table shows the different instruments per category. c Number and combination of PRO instruments per ICI-CT per year of start of the trial. For FACT questionnaires that include core domains of the FACT-G, both cancer-specific and disease specific have been depicted (see Table S4 for more detail). For ICI-CTs colored in light grey PRO results have been published (n = 26)

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