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Table 1 Summary of Meaningful Change Thresholds

From: Evaluation of meaningful change in bowel movement frequency for patients with carcinoid syndrome

Parameter Threshold for Acceptability Analysis Population Average Number of Daily BMs
Overall Change from Baseline Change from Baseline at Week 12
N ES Mean N ES Mean
Anchor-based Meaningful Change Thresholds
Adequate relief (changed to Yes at Week 12) Effect Size:
-Small (≥ 0.2)
-Moderate (≥ 0.5)
-Large (≥ 0.8)
ITT 19 −1.20 −1.90 18 −1.58 −2.52
EORTC QLQ-C30 Diarrhea (Responder) ITT 45 −0.83 −1.71 40 −1.24 −2.56
EORTC GI.NET21 GI Symptoms (Responder) ITT 30 −1.25 −1.88 25 −1.49 −2.27
Distribution-based Meaningful Change Thresholds
−1/2 Baseline SD N/A ITT 135 N/A 0.62 108 N/A 0.86
  1. BM Bowel movement, EORTC QLQ-C30 European Organization for Research and Treatment of Cancer Quality of Life Questionnaire - Core Questionnaire, ES Effect size, ITT Intent-to-treat, N/A Not applicable, SD Standard deviation
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