Skip to main content

Table 6 Known-Groups Validity – ASDD by HDSS, Gravimetry, and DLQI/CDLQI severity thresholds at Week 4

From: Development and validation of the Axillary Sweating Daily Diary: a patient-reported outcome measure to assess axillary sweating severity

   Phase 2:
DRM04-HH02
(N = 105)
Phase 3 Pooled: ATMOS-1 & ATMOS-2
Age 9–15 Years (N = 32) Age ≥ 16 Years (N = 665)
ASDD Item 2 (Week 4 Average) HDSS, mean (SD)
Grade 1 0.9 ± 1.2 (n = 35) 2.0 ± 0.6 (n = 5) 1.1 ± 1.6 (n = 208)
Grade ≥ 3 5.3 ± 1.4 (n = 14) 6.8 ± 1.86 (n = 13) 6.5 ± 2.1 (n = 154)
p-value < 0.001 < 0.001 < 0.001
Sweat Production,a mean (SD)
1st Quartile 1.8 ± 1.7 (n = 19) 4.1 ± 3.2 (n = 3) 2.6 ± 2.6 (n = 166)
4th Quartile 3.4 ± 2.0 (n = 20) 6.3 ± 1.9 (n = 15) 4.2 ± 2.8 (n = 168)
p-value 0.009 0.125 < 0.001
DLQI/C-DLQI, mean (SD)
No to moderate impact N/A 4.4 ± 2.5 (n = 27) 2.9 ± 2.5 (n = 571)
Very large to extremely large impact N/A 9.8 (n = 1) 7.3 ± 2.4 (n = 7)
p-value N/A N/Ab < 0.001
ASDD Item 3 (Week 4 Average) HDSS, mean (SD)
Grade 1 0.2 ± 0.4 (n = 35) N/A 0.2 ± 0.3 (n = 182)
Grade ≥ 3 1.5 ± 0.7 (n = 14) N/A 2.1 ± 1.0 (n = 114)
p-value < 0.001 N/A < 0.001
Sweat Production,a mean (SD)
1st Quartile 0.5 ± 0.6 (n = 19) N/A 0.7 ± 0.8 (n = 146)
4th Quartile 1.0 ± 0.7 (n = 20) N/A 1.2 ± 1.0 (n = 134)
p -value 0.026 N/A < 0.001
DLQI/C-DLQI, mean (SD)
No to moderate impact N/A N/A 0.8 ± 0.9 (n = 508)
Very large to extremely large impact N/A N/A 3.0 ± 1.0 (n = 5)
p -value N/A N/A < 0.001
ASDD Item 4 (Week 4 Average) HDSS, mean (SD)
Grade 1 0.2 ± 0.3 (n = 35) N/A 0.2 ± 0.3 (n = 182)
Grade ≥ 3 1.7 ± 0.7 (n = 14) N/A 2.3 ± 1.0 (n = 114)
p -value < 0.001 N/A < 0.001
Sweat Production,a mean (SD)
1st Quartile 0.5 ± 0.5 (n = 19) N/A 0.8 ± 0.8 (n = 146)
4th Quartile 1.2 ± 0.7 (n = 20) N/A 1.3 ± 1.0 (n = 134)
p -value 0.002 N/A < 0.001
DLQI/C-DLQI, mean (SD)
No to moderate impact N/A N/A 0.9 ± 0.9 (n = 508)
Very large to extremely large impact N/A N/A 3.0 ± 1.1 (n = 5)
p -value N/A N/A < 0.001
  1. ASDD Axillary Sweating Daily Diary, HDSS Hyperhidrosis Disease Severity Scale, SD Standard deviation
  2. a Measured gravimetrically; bNot calculable due to sample size (N = 1)
  3. P value for two sample t-test
  4. HDSS Grade 1 = My sweating is never noticeable and never interferes with my daily activities; Grade 3 = My sweating is barely tolerable and frequently interferes with my daily activities; Grade 4 = My sweating is intolerable and always interferes with my daily activities
  5. Quartiles for gravimetric measurement of sweat production at Week 4 defined as 25th percentile (8.7 mg/axilla/5 min) and 75th percentile (34.95 mg/axilla/5 min)
  6. DLQI: no to moderate impact = range 0–10; large to extremely large impact = range 21–30; CDLQI: no to moderate impact = range 0–12; large to extremely large impact = range 19–20
\