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Table 5 ASDD Construct Validity Correlations at Week 4 (Phase 2 data; N = 105 or Phase 3 data; N = 697)

From: Development and validation of the Axillary Sweating Daily Diary: a patient-reported outcome measure to assess axillary sweating severity

ASDD Item

 

HDSS Grade, Pearson correlation

Sweat Production,a Pearson correlation

DLQI/C-DLQI, Spearman correlation

Weekly Impact Summary, Pearson correlation

PGIC, Spearman correlation

Week 4 Average

 Axillary Sweating Severity (Item 2)

Phase 2

0.73*

0.33*

N/A

0.52*

0.62*

Phase 3 9–15yo

0.71*

0.17

0.51*

N/A

N/A

Phase 3 ≥ 16yo

0.70*

0.18*

0.61*

0.66*

0.70*

 Impact (Item 3)

Phase 2

0.71*

0.24*

N/A

0.62*

0.65*b

Phase 3 Pooled

0.72*

0.13*

0.65*

0.68*

0.65*

 Bothersomeness (Item 4)

Phase 2

0.79*

0.27*

0.64*

0.70*b

Phase 3 Pooled

0.74*

0.13*

0.66*

0.69*

0.66*

Change from Baseline to Week 4

 Axillary Sweating Severity (Item 2)

Phase 2

0.57*

0.17

N/A

0.65*

0.48*

Phase 3 9–15yo

0.71*

0.17

0.51*

N/A

N/A

Phase 3 ≥ 16yo

0.70*

0.18

0.63*

0.62*

0.68*

 Impact (Item 3)

Phase 2

0.51*

0.05

N/A

0.57*

0.27*

Phase 3 Pooled

0.64*

0.01

0.51*

0.65*

0.57*

 Bothersomeness (Item 4)

Phase 2

0.58*

0.13

N/A

0.61*

0.31*

Phase 3 Pooled

0.65*

0.02

0.53*

0.65*

0.59*

  1. ASDD Axillary Sweating Daily Diary, HDSS Hyperhidrosis Disease Severity Scale, PGIC Patient Global Impression of Change
  2. *p ≤ 0.05
  3. a Measured gravimetrically
  4. b Weekly average for PGIC is not applicable
  5. Entries marked N/A indicate that the assessment was not performed for that study and/or population