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Table 3 Relationship (Spearman’s correlations) of UFS-QOL scale scores with bleeding diary assessments in VENUS I and VENUS II and PGI-I in VENUS II after 12 weeks of treatment; per protocol population (patient-reported outcome approach)

From: Psychometric validation of the 1-month recall Uterine Fibroid Symptom and Health-Related Quality of Life questionnaire (UFS-QOL)

  VENUS I VENUS II
UFS-QOL Bleeding daysa Heavy bleeding daysb Bleeding daysa Heavy bleeding daysb PGI-I
Symptom Severity 0.59 0.56 0.62 0.60 0.69
Concern −0.61 −0.58 −0.63 −0.63 −0.70
Activities −0.63 −0.63 −0.54 −0.58 −0.67
Revised Activities −0.63 −0.63 −0.53 −0.57 −0.66
Energy/Mood −0.56 −0.58 −0.44 −0.51 −0.57
Control −0.49 −0.54 −0.46 −0.52 −0.58
Self-Consciousness −0.43 −0.41 −0.42 −0.47 −0.53
Sexual Function −0.44 −0.47 −0.35 −0.40 −0.48
HRQoL Total −0.61 −0.62 −0.53 −0.58 −0.66
  1. All p < 0.0001
  2. aNumber of days in previous 35 days – “bleeding”: days with rating of “bleeding” and “heavy bleeding”
  3. b“Heavy bleeding”: days with rating of “heavy bleeding”. HRQoL health-related quality of life; PGI-I Patient Global Impression of Improvement scale; UFS-QOL Uterine Fibroid Symptom and Health-Related Quality of Life questionnaire
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