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Table 2 Final PRO-CTCAE Item Selection Process

From: Patient-reported outcomes item selection for bladder cancer patients in chemo- or immunotherapy

Focus group interviews Overall PRO-CTCAE symptoms grade 2-4 for 29 patients* (listed by falling frequency, %) PRO-CTCAE symptoms grade 2-4 in relation to hospital admission (patients receiving n=13 chemo- / n=7 immunotherapy)** Final included PRO-CTCAE symptom
Nurses, n=3 Doctors, n=4
Urinary symptoms Urinary symptoms/catheter problems/infections Frequent urination (48) Frequent urination (2) Frequent urination
Fatigue Fatigue Fatigue (36) Fatigue (9) Fatigue
Urinary urgency (30)  
Dry mouth (25) Dry mouth (2)
Nausea Nausea Nausea (22) Nausea (4) Nausea
Pain Pain General pain (22) General pain (7) Pain
Decreased appetite Decreased appetite Decreased appetite (21) Decreased appetite (4) Decreased appetite
Swelling Swelling Swelling (21) Swelling (5) Swelling
Insomnia Insomnia (20) Insomnia (5) Insomnia
Shortness of breath Shortness of breath (19) Shortness of breath (5) Shortness of breath
Constipation Constipation (15) Constipation (1) Constipation
Abdominal pain Abdominal pain (15) Abdominal pain (5)
Sad (15)  
Heart palpitations Heart palpitations (14) Heart palpitations (1) Heart palpitations
Painful urination (13)  
Muscle pain (12) Muscle pain (3)
Taste changes   Taste changes (12) Taste changes (3)
Decreased libido (11)  
Urinary incontinence (11)  
Diarrhea Diarrhea (11) Diarrhea (4) Diarrhea
Chills (11) Chills (1) Chills
Cough (10)  
Headache (10)  
Neuropathy Numbness & tingling (9)  
Dry skin (9) Dry skin (1)
Discouraged (8)  
Ringing in ears (8)  
Itching (7) Itching (1) Itching
Anxiety   Anxious (6)   Anxious
Dizziness (5)  
Difficulty swallowing (5)  
Increased sweating (4)  
Mouth /throat soars (4)  
Joint pain (4) Joint pain (1)
Heartburn (3)  
Blurred vision (3)  
Hair loss (3)  
Hot flashes/flushes (2)  
Vomiting Vomiting (2)   Vomiting
Memory (1) Memory (1)
Concentration (1) Concentration (1)
Weight loss   
Stomatitis   
  1. aOf the 30 patients enrolled in study 1, only 29 initiated treatment
  2. bOf the 27 patients in study 2 experiencing hospital admission, only 20 (13 chemotherapy / 7 immunotherapy) patients had a completed questionnaire in relation to the hospital admission
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