Table 3 Qualitative support for MSQ v2.1 ePRO RFR domain concepts

Item 1: Interfere with family, friends, and others

• At first some of my friends would think I didn’t want to really go out with them because, you know, it [cancelling] would happen repeatedly.

• Definitely for me it affects how I feel my relationships with people are, you know.

Item 2: Interfere with leisure time activities

• Physical activity is something that I do for leisure. So, sometimes I can’t do that.

• I--really I love to play tennis and golf and read, and so it [migraine attacks] affects all of those.

Item 3: Difficulty performing work or daily activities

• I’ve been at work before and had to either lay down and fight through them just for a little bit or, sometimes I’ve just had to leave work and go home.

• I have to modify my lesson plan for my students, because I really can’t present a lot in front of them.

• It’s just so hard for me to just function to drive—to drive a car, to do, you know, all these things that are normally required of people.

• Work as I have been saying, I just force myself to power through it.

Item 4: Keep you from getting as much done at work or at home

• When I say I can’t function, I can’t cook. I can’t clean up anything. I can’t--just simple tasks that you would think, you know, talking on the phone. I can’t even look at my phone, because the light on the phone just sends me into a whirlwind of just like haze.

• I couldn’t get things done… things for work.

• I go to work even with or without a migraine attack. I’m sure I’m not able to work as efficiently.

• I might have been able to get some stuff, but was I actually able to get all of it? And the general answer would be no. I wouldn’t be able to get everything I wanted done because I’m either moving slower, or I’m making mistakes.

Item 5: Limit your ability to concentrate

• I feel like you kind of lose a sense of, um, being able to focus, you know, because all you feel is my head hurts this bad. I don’t know what you’re saying to me right now or what, you know. Just the processing is slowed down for sure.

• My ability to focus on what I’m trying to read and follow the words and everything has diminished a lot.

Item 6: Left you too tired

• You’re exhausted from how bad your head hurt, you know that whole time. So, I would definitely say, um, the majority of the fatigue is after the worst part of the pain has subsided.

• Using an example of grading papers… I’m just too tired. I’m not going to do it, so.

• I guess post-migraine attack residual headache, um, that’s like I’m so lethargic. I’m like a sloth.

Item 7: Limited the number of days you felt energetic

• It does affect the energy level. I—I mean, I, you know, most of the time I wake up in the morning even if it’s a really mild headache I feel like it’s like, okay. Here’s another headache, you know. I—I don’t have a—it definitely takes a lot of energy out of me.

• When it’s [migraine attack] really bad, my energy is, you know, sinks pretty low.