A review of HIV-specific patient-reported measures of perceived barriers to antiretroviral therapy adherence: what themes are they covering?

Engler, Kim; Toupin, Isabelle; Vicente, Serge; Ahmed, Sara; Lebouché, Bertrand

doi:10.1186/s41687-019-0124-3

Journal of Patient-Reported Outcomes

Table 1 Instrument characteristics (n = 31)

From: A review of HIV-specific patient-reported measures of perceived barriers to antiretroviral therapy adherence: what themes are they covering?

#	Instrument/study name (if appropriate)	First author of related publication	Version year	Country^b	Description	Patient involvement		No. items^a
#	Instrument/study name (if appropriate)	First author of related publication	Version year	Country^b	Description	Yes	No	No. items^a
1	Adult AIDS Clinical Trials Group (AACTG), Adherence Baseline Questionnaire II, 2001, Section C	Chesney et al. 2000 [21]	2001	USA	“Reasons why people may miss taking their medications”^c		●	14
2	AACTG, Adherence Barriers Questionnaire, 2008, Question 2	Chesney et al. 2000 [21]	2008	USA	“Reasons why people may miss taking their medications”^c		●	22
3	–	Amico et al. 2007 [22]	2007	USA	“Reasons for last having missed a dose of ART medication”		●	14
4	AACTG adherence instrument -Modified	Barfod et al. 2006 [23]	2006	Denmark	“Reasons for missing a dose”^c	●		22
5	–	Boretzki et al. 2017 [24]	2017	Germany	“Reasons for nonadherence to antiretroviral therapy”		●	9
6	CEAT-VIH (Cuestionario para la Evaluacio’n de la Adhesio’n al Tratamiento Antirretroviral en Personas con Infeccio’n por VIH y Sida) -Romanian adaptation	Dima et al. 2013 [25] (based on Remor 2002)	2013	Romania	“Barriers to adherence” -“Antecedents of non-adherence behaviours”	●		3
7	–	Durante et al. 2003 [26]	2003	USA	“Reasons for missing doses of medication”^c	●		14
8	–	Gifford et al. 2000 [27]	2000	USA	“Reasons for missing antiretroviral doses”		●	16
9	Questionnaire on Taking Antiretroviral Medication, Questions 3 and 4	Godin et al. 2003 [28]	2003	Canada	“Situations that might have hampered […] regular adherence to medication”	●		8
10	HIV Futures 3 Survey	Grierson et al. 2004 [29]	2004	Australia	“Reasons for taking treatment breaks”- Lifestyle and clinical reasons	●		16
11	HIV Futures 7 Survey	Grierson et al. 2013 [30]	2013	Australia	“Reasons for stopping ARV”	●		7
12	HIV Futures 7 Survey	Grierson et al. 2013 [30]	2013	Australia	“Reasons for taking breaks” -Lifestyle and clinical reasons	●		14
13	–	Harzke et al. 2004 [31]	2004	USA	“Perceived barriers to taking antiretrovirals” –“Forgetting to take medications” scale		●	3
14	HCSUS 2nd Follow-up, Section 4.5 Antiretroviral and Opportunistic Infection Medication	n.a.	1997	USA	“Reasons […] why you stopped taking this antiretroviral medication(s)”		●	11
15	–	Kalichman et al. 1999 [32]	1999	USA	“Perceived barriers to treatment and reasons for non-adherence”		●	9
16	–	Kalichman et al. 2017 [33]	2017	USA	“Barriers to adherence”		●	15
17	AACTG adherence instrument -Supplemented for the Vancouver Injection Drug Users Study (VIDUS)	Kerr et al. 2004 [34]	2004	Canada	“Reasons for missing doses of HAART”^c		●	13
18	Vancouver Injection Drug Users Study (VIDUS) questionnaire	Kerr et al. 2005 [35]	2005	Canada	“Reasons for discontinuing HAART”		●	15
19	AACTG adherence instrument -Adapted for the Multicenter AIDS Cohort Study (MACS), Medication Adherence Form	Kleeberger et al. 2001 [36]	2001	USA	“Reasons for missing […] medications”^c	●		15
20	The study to understand the natural history of HIV/AIDS in the era of effective therapy (SUN) study, questionnaire	Kyser et al. 2011 [37]	2011	USA	“Main reason […] for missing medication”		●	6
21	–	Macdonell et al. 2013 [38]	2013	USA	“Barriers to medication adherence”		●	18
22	Community Programs for Clinical Research on AIDS (CPCRA), Antiretroviral Medication Self-Report -Form 646, Version 4, 2003, Section C, Question 2	Mannheimer et al. 2002 [39]	2003	USA	“Reasons why people miss taking their antiretroviral drugs”		●	10
23	AACTG adherence instrument -Adapted	Murphy et al. 2000 [40]	2000	USA	“Barriers to adherence”^c		●	23
24	AACTG adherence instrument -Supplemented by adolescent-specific issues for the Reaching for Excellence in Adolescent Care and Health (REACH) Project	Murphy et al. 2003 [41]	2003	USA	“Barriers to adherence”^c		●	19
25	The HIV Epidemiology Research Study (HERS) and Women’s Inter-Agency HIV Study (WIHS), substudy interview instruments	Schuman et al. 2001 [42]	2001	USA	“Reasons that occasionally or frequently interfered with adherence”		●	11
26	US Military HIV Natural History Cohort Study (NHS), HIV Medication Adherence History, Form 168.40.1	n.a.	2010	USA	“Reasons for missed doses”		●	23
27	HIV Medication Self-Reported Nonadherence Reasons (SNAR) Index	Schönnesson et al. 2004 [43]	2004	Sweden	“Reasons for nonadherence to HIV-medication” -Medication concerns and routine disruptions^c		●	11
28	AACTG adherence instrument -Modified for the New York City Study	Stirratt et al. 2006 [44]	2006	USA	“Reasons for missed ART doses”^c		●	22
29	–	Walsh et al. 2001 [45]	2001	UK	“Reasons for missing doses”	●		20
30	–	Zorilla et al. 2003 [46]	2003	USA (Puerto Rico)	“Reasons for not taking medications”		●	8
31	–	Zorilla et al. 2003 [46]	2003	USA (Puerto Rico)	“Reasons for taking medications at a different time”		●	7

# = Number assigned to the instrument, as in Table 2
^aNumber of specific items (e.g., does not include space provided for “other” elements not included in the measure)
^bAs indicated by the publications considered in this review (may not be exhaustive)
^cAACTG adherence instrument or derivative thereof, as reported by developers

Back to article page