Evaluation of the psychometric properties and minimally important difference of the MD Anderson Symptom Inventory for malignant pleural mesothelioma (MDASI-MPM)

Journal of Patient-Reported Outcomes

Table 6 Meaningful change estimation using 2 different approaches

Anchor-based estimation of meaningful change
	n	Improvement (all n = 61)	No change (n = 70)	Decline (all n = 52)
MDASI-MPM symptoms^a	183	1.05 (1.96)	0.16 (1.46)	−0.65 (1.30)
MDASI-MPM interference^a	181	1.07 (3.19)	0.18 (2.19)	−0.92 (2.16)
Distribution-based estimation of meaningful change
	n	One-half SD	One-third SD	SEM
MDASI-MPM symptoms^a	183	0.79	0.52	0.76
MDASI-MPM interference^a	181	1.26	0.83	1.27

^aMDASI-MPM symptoms = the average of the 13 core and 6 MPM-specific items. MDASI-MPM interference = the average of the 6 interference items
Anchor = Global QOL item (0–100 scale) from the LCSS-Meso
Abbreviations: MDASI-MPM MD Anderson Symptom Inventory for malignant pleural mesothelioma, SD standard deviation, SEM standard error of the mean