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Table 5 Sensitivity of the MDASI-MPM based on changes in ECOG Performance Status (PS)

From: Evaluation of the psychometric properties and minimally important difference of the MD Anderson Symptom Inventory for malignant pleural mesothelioma (MDASI-MPM)

 

Patients with worsening PS from baseline to safety follow-up (n = 50)

Baseline Mean (SD)

Safety follow-up Mean (SD)

95% CI

Effect Size

MDASI-MPM subscale

 MDASI-MPM symptomsa

2.2 (1.6)

3.2 (1.9)

− 1.5 to − 0.5

0.69

 MDASI-MPM interferencea

2.8 (2.4)

5.0 (2.8)

−3.0 to − 1.4

0.92

MDASI-MPM symptom

 Trouble with balance or fallingb

0.9 (1.6)

2.7 (3.0)

1.0 to 2.7

1.13

 Eye problemsb

0.5 (1.3)

1.7 (2.2)

0.4 to 1.8

0.92

 Muscle weaknessb

2.4 (2.6)

4.5 (3.3)

1.3 to 2.9

0.81

 Numbnessb

1.7 (2.7)

3.7 (3.3)

1.1 to 2.9

0.74

 Dry mouthb

1.7 (2.2)

3.0 (2.4)

0.5 to 2.1

0.59

 Fatigue

4.2 (2.5)

5.4 (2.5)

0.4 to 2.0

0.48

 Feeling sad

1.9 (2.6)

3.1 (3.3)

0.4 to 2.0

0.46

 Feeling malaise

2.5 (2.6)

3.7 (3.0)

0.2 to 2.2

0.46

 Lack of appetite

2.4 (2.7)

3.5 (2.7)

0.1 to 2.2

0.41

 Distress

2.4 (2.4)

3.3 (3.0)

0.1 to 1.6

0.38

 Shortness of breath

3.6 (2.4)

4.5 (3.0)

−0.1 to 1.8

0.38

 Chest heaviness

2.2 (2.2)

3.0 (2.9)

.01 to 1.5

0.36

 Pain

3.5 (2.7)

4.3 (2.9)

−0.1 to 1.6

0.30

 Feeling drowsy

2.8 (2.7)

3.5 (2.9)

−0.2 to 1.6

0.26

 Coughing

2.7 (2.8)

2.0 (2.2)

−1.4 to 0.1

0.25

 Difficulty remembering

1.6 (2.1)

2.1 (2.5)

−0.1 to 1.1

0.24

 Disturbed sleep

2.8 (2.9)

3.2 (2.7)

−0.5 to 1.4

0.14

 Nausea

1.4 (1.9)

1.2 (1.9)

−0.4 to 0.8

0.11

 Vomiting

0.7 (1.5)

0.8 (1.3)

−0.3 to 0.6

0.07

  1. aMDASI-MPM symptoms = the average of the 13 core and 6 MPM-specific items. MDASI-MPM interference = the average of the 6 interference items
  2. bSignificant at P < 0.01
  3. Abbreviations: MDASI-MPM MD Anderson Symptom Inventory for malignant pleural mesothelioma, SD standard deviation