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Table 6 Changes in ASD Minimal Symptom Days in a 7-Day Period by ACQ Change Groups at Weeks 12 and 24

From: Evaluating minimal important differences and responder definitions for the asthma symptom diary in patients with moderate to severe asthma

ACQ Group Minimal Symptom Days-1 Minimum Symptom Days-2
Week 12 Week 24 Week 12 Week 24
1 Change ≤ −1.0 [Responder] 2.43 3.23 2.31 2.56
2 Change −0.5 to −1.0 [MID] 1.97 2.16 1.02 1.36
3 Change ≥ −0.5 0.60 0.54 −0.01 0.08
Model p-value < 0.0001 < 0.0001 < 0.0001 < 0.0001
Significant contrasts (p < 0.01) 1v3; 2v3 1v2; 1v3; 2v3 1v3; 2v3 1v2; 1v3; 2v3
  1. Minimal Symptom Days-1 defined as mean of the 10 ASD daily symptom items ≤1 and no single symptom item score > 1
  2. Minimal Symptom Days-2 defined as no single ASD daily symptom item score > 1, and activity limitations or nighttime awakening item scores = 0