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Journal of Patient-Reported Outcomes

Table 6 Changes in ASD Minimal Symptom Days in a 7-Day Period by ACQ Change Groups at Weeks 12 and 24

From: Evaluating minimal important differences and responder definitions for the asthma symptom diary in patients with moderate to severe asthma

ACQ Group

Minimal Symptom Days-1

Minimum Symptom Days-2

Week 12

Week 24

Week 12

Week 24

1 Change ≤ −1.0 [Responder]

2.43

3.23

2.31

2.56

2 Change −0.5 to −1.0 [MID]

1.97

2.16

1.02

1.36

3 Change ≥ −0.5

0.60

0.54

−0.01

0.08

Model p-value

< 0.0001

< 0.0001

< 0.0001

< 0.0001

Significant contrasts (p < 0.01)

1v3; 2v3

1v2; 1v3; 2v3

1v3; 2v3

1v2; 1v3; 2v3

  1. Minimal Symptom Days-1 defined as mean of the 10 ASD daily symptom items ≤1 and no single symptom item score > 1
  2. Minimal Symptom Days-2 defined as no single ASD daily symptom item score > 1, and activity limitations or nighttime awakening item scores = 0
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