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Table 3 Responsiveness of ASD Minimal Symptom Days in a 7-Day Period at Weeks 12 and 24

From: Evaluating minimal important differences and responder definitions for the asthma symptom diary in patients with moderate to severe asthma

  Responders Mean (SE) Non-Responders Mean (SE) Difference P-Value
Minimal Symptom Days-1
 Week 12
  ACQ > 0.5 2.29 (0.17) 0.61 (0.18) 1.68 p < 0.001
  Effect size 0.80 0.21
  ACQ > 1.0 2.41 (0.20) 0.96 (0.16) 1.45 p < 0.001
  Effect size 0.85 0.34
  PGA 2.46 (0.17) 0.48 (0.17) 1.98 p < 0.001
  Effect size 0.86 0.17
  Week 24     
  ACQ > 0.5 2.91 (0.18) 0.50 (0.24) 2.41 p < 0.001
  Effect size 1.02 0.18
  ACQ > 1.0 3.21 (0.21) 0.98 (0.20) 2.23 p < 0.001
  Effect size 1.13 0.34
  PGA 3.01 (0.19) 0.63 (0.23) 2.38 p < 0.001
  Effect size 1.06 0.22
Minimal Symptom Days-2
 Week 12
  ACQ > 0.5 1.93 (0.16) 0.04 (0.17) 1.97 p < 0.001
  Effect size 0.85 0.02
  ACQ > 1.0 2.29 (0.19) 0.29 (0.15) 2.05 p < 0.001
  Effect size 1.01 0.13
  PGA 1.79 (0.17) 0.20 (0.18) 1.59 p < 0.001
  Effect size 0.79 0.09
 Week 24
  ACQ > 0.5 2.26 (0.18) 0.06 (0.28) 2.20 p < 0.001
  Effect size 1.00 0.03
  ACQ > 1.0 2.61 (0.21) 0.44 (0.19) 2.17 p < 0.001
  Effect size 1.15 0.19
  PGA 2.14 (0.19) 0.42 (0.24) 1.72 p < 0.001
  Effect size 0.94 0.19
  1. Minimal Symptom Days-1 defined as mean of the 10 ASD daily symptom items ≤1 and no single symptom item score > 1
  2. Minimal Symptom Days-2 defined as no single ASD daily symptom item score > 1, and activity limitations or nighttime awakening item scores = 0