Evaluating minimal important differences and responder definitions for the asthma symptom diary in patients with moderate to severe asthma

Journal of Patient-Reported Outcomes

Table 2 Responsiveness of ASD Symptomatic Days in a 7-Day Period at Weeks 12 and 24

	Responders Mean (SE)	Non-Responders Mean (SE)	Difference	P-Value
Week 12
ACQ > 0.5	−2.21 (0.16)	−0.57 (0.18)	−1.64	p < 0.001
Effect size	0.73	0.19	−1.64	p < 0.001
ACQ > 1.0	−2.35 (0.20)	−0.90 (0.16)	−1.45	p < 0.001
Effect size	0.78	0.30	−1.45	p < 0.001
PGA	−2.34 (0.16)	−0.45 (0.17)	−1.86	p < 0.001
Effect size	0.78	0.15	−1.86	p < 0.001
Week 24
ACQ > 0.5	−2.86 (0.18)	− 0.28 (0.28)	− 2.57	p < 0.001
Effect size	0.95	0.09	− 2.57	p < 0.001
ACQ > 1.0	−3.21 (0.21)	−0.77 (0.20)	−2.44	p < 0.001
Effect size	1.07	0.26	−2.44	p < 0.001
PGA	−2.97 (0.19)	−0.45 (0.23)	−2.52	p < 0.001
Effect size	0.99	0.15	−2.52	p < 0.001

Symptomatic Days defined as mean of the 10 ASD daily symptom items ≥1, otherwise non-Symptomatic Day