Psychometric validation of the work productivity and activity impairment questionnaire in ulcerative colitis: results from a systematic literature review

Journal of Patient-Reported Outcomes

Table 6 Changes in WPAI scores over time as a function of change in UC disease activity status

					Change in mean WPAI scores from Time 1 to Time 2
Study	N	Time 1 status	Time 2 status	Interval	Absenteeism	Presenteeism	OWI	Activity Impairment
Yarlas 2015b [37]	180	Active	Remission	8 weeks^a	− 8.7	−26.0	− 28.0	−30.1
Yarlas 2015b [37]	258	Remission	Active	12 months^b	9.4	19.4	25.4	22.3

OWI Overall Work Impairment; UC ulcerative colitis; WPAI Work Productivity and Activity Impairment questionnaire
^aReceiving multimatrix mesalamine 4.8 g/day once daily
^bReceiving multimatrix mesalamine 2.4 g/day once daily
Remission defined as UC-DAI total score ≤ 1, rectal bleeding and stool frequency components = 0, and ≥ 1-point reduction in endoscopy score
from induction phase baseline
Values printed in BOLD indicating those exceeding established thresholds indicating clinically important change