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Table 6 Changes in WPAI scores over time as a function of change in UC disease activity status

From: Psychometric validation of the work productivity and activity impairment questionnaire in ulcerative colitis: results from a systematic literature review

  Change in mean WPAI scores from Time 1 to Time 2
Study N Time 1 status Time 2 status Interval Absenteeism Presenteeism OWI Activity Impairment
Yarlas 2015b [37] 180 Active Remission 8 weeksa − 8.7 −26.0 − 28.0 −30.1
Yarlas 2015b [37] 258 Remission Active 12 monthsb 9.4 19.4 25.4 22.3
  1. OWI Overall Work Impairment; UC ulcerative colitis; WPAI Work Productivity and Activity Impairment questionnaire
  2. aReceiving multimatrix mesalamine 4.8 g/day once daily
  3. bReceiving multimatrix mesalamine 2.4 g/day once daily
  4. Remission defined as UC-DAI total score ≤ 1, rectal bleeding and stool frequency components = 0, and ≥ 1-point reduction in endoscopy score
  5. from induction phase baseline
  6. Values printed in BOLD indicating those exceeding established thresholds indicating clinically important change