Psychometric validation of the work productivity and activity impairment questionnaire in ulcerative colitis: results from a systematic literature review

Journal of Patient-Reported Outcomes

Table 2 Changes in WPAI scores over time for patients with no change in UC disease activity status

				Change in mean WPAI scores from Time 1 to Time 2
Study	N	Status at both assessments	Interval	Absenteeism	Presenteeism	OWI	Activity Impairment
Yarlas 2015b [37]	45	Complete remission^a	12 months^c	− 0.5	−4.2	− 4.8	0.2
Yarlas 2015b [37]	53	Partial remission^b	12 months^c	− 4.3	−1.1	−4.9	− 1.6
Weighted Mean differences^d				− 2.6	−2.5	−4.9	−0.8

OWI Overall Work Impairment, UC ulcerative colitis, WPAI Work Productivity and Activity Impairment questionnaire
^aComplete remission defined as UC-DAI total score ≤ 1, rectal bleeding and stool frequency components = 0, and ≥ 1-point reduction in endoscopy score from induction phase baseline
^bPartial remission defined as UC-DAI total score ≤ 3, combined score on rectal bleeding and stool frequency components ≤1, and not in complete remission
^cReceiving multimatrix mesalamine 2.4 g/day once daily
^dWeighted by sample size