Skip to main content

Advertisement

Table 5 Means, standard deviations, and traditional concordance metrics for patient adverse events

From: Application of a Bayesian graded response model to characterize areas of disagreement between clinician and patient grading of symptomatic adverse events

  Mean (Standard Deviation) Concordance Metric
PRO-CTCAE CTCAE
Adverse Event Frequency Severity Interference Grade Weighted κ Spearman r %
Anxiety 1.18 (1.08) 1.55 (0.79) 1.07 (1.13) 0.48 (0.66) 0.05 0.36* 0.28
Dyspnea ** 0.69 (0.93) 1.32 (1.13) 0.34 (0.60) 0.41* 0.58* 0.64
Edema 0.57 (1.10) 1.68 (0.88) 1.17 (1.28) 0.16 (0.41) 0.07 0.13 0.22
Fatigue ** 1.68 (1.07) 1.80 (1.14) 0.98 (0.77) 0.25* 0.48* 0.37
Feeling Nothing/Cheer Up 0.67 (0.96) 1.43 (0.83) 1.17 (1.05) 0.30 (0.55) 0.09 0.30* 0.25
Headache 0.74 (0.95) 1.46 (0.71) 0.96 (1.00) 0.20 (0.46) 0.05 0.21* 0.19
Insomnia ** 1.13 (1.12) 1.43 (1.12) 0.51 (0.71) 0.29* 0.50* 0.48
Mucositis ** 0.42 (0.84) 1.09 (1.19) 0.16 (0.49) 0.35* 0.47* 0.77
Nausea 0.86 (1.07) 1.55 (0.86) ** 0.33 (0.56) 0.09 0.31* 0.28
Pain 1.35 (1.29) 1.89 (0.95) 1.62 (1.25) 0.61 (0.79) 0.15 0.44* 0.25
Problems w/Concentration ** 0.71 (0.90) 1.24 (0.98) 0.34 (0.54) 0.30* 0.43* 0.58
Sad/Unhappy Feelings 1.14 (0.99) 1.42 (0.76) 0.94 (1.04) 0.30 (0.55) 0.08 0.39* 0.21
Vomiting 0.29 (0.71) 1.51 (0.94) ** 0.10 (0.36) 0.10 0.34* 0.25
  1. Note: Concordance was calculated between PRO-CTCAE severity and CTCAE ratings, ** indicates attribute not assessed, * indicates significant p < 0.01