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Table 5 Means, standard deviations, and traditional concordance metrics for patient adverse events

From: Application of a Bayesian graded response model to characterize areas of disagreement between clinician and patient grading of symptomatic adverse events

 

Mean (Standard Deviation)

Concordance Metric

PRO-CTCAE

CTCAE

Adverse Event

Frequency

Severity

Interference

Grade

Weighted κ

Spearman r

%

Anxiety

1.18 (1.08)

1.55 (0.79)

1.07 (1.13)

0.48 (0.66)

0.05

0.36*

0.28

Dyspnea

**

0.69 (0.93)

1.32 (1.13)

0.34 (0.60)

0.41*

0.58*

0.64

Edema

0.57 (1.10)

1.68 (0.88)

1.17 (1.28)

0.16 (0.41)

0.07

0.13

0.22

Fatigue

**

1.68 (1.07)

1.80 (1.14)

0.98 (0.77)

0.25*

0.48*

0.37

Feeling Nothing/Cheer Up

0.67 (0.96)

1.43 (0.83)

1.17 (1.05)

0.30 (0.55)

0.09

0.30*

0.25

Headache

0.74 (0.95)

1.46 (0.71)

0.96 (1.00)

0.20 (0.46)

0.05

0.21*

0.19

Insomnia

**

1.13 (1.12)

1.43 (1.12)

0.51 (0.71)

0.29*

0.50*

0.48

Mucositis

**

0.42 (0.84)

1.09 (1.19)

0.16 (0.49)

0.35*

0.47*

0.77

Nausea

0.86 (1.07)

1.55 (0.86)

**

0.33 (0.56)

0.09

0.31*

0.28

Pain

1.35 (1.29)

1.89 (0.95)

1.62 (1.25)

0.61 (0.79)

0.15

0.44*

0.25

Problems w/Concentration

**

0.71 (0.90)

1.24 (0.98)

0.34 (0.54)

0.30*

0.43*

0.58

Sad/Unhappy Feelings

1.14 (0.99)

1.42 (0.76)

0.94 (1.04)

0.30 (0.55)

0.08

0.39*

0.21

Vomiting

0.29 (0.71)

1.51 (0.94)

**

0.10 (0.36)

0.10

0.34*

0.25

  1. Note: Concordance was calculated between PRO-CTCAE severity and CTCAE ratings, ** indicates attribute not assessed, * indicates significant p < 0.01