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Table 5 Anchor-based CID estimates for improvement for the FACT-Cog total score (33 item) and FACT-Cog-PCI based on changes from baseline at post-intervention (T2) and six month follow-up (T3) and secondary anchor FACT-G. Correlations, ρ, are for the change in the FACT-Cog total score or PCI subscale and the categorized anchor changes

From: Important differences and meaningful changes for the Functional Assessment of Cancer Therapy-Cognitive Function (FACT-Cog)

FACT-Cog scale Time, Anchor Anchor changea N (%) Mean change in FACT-Cog (SD) MCT Estimateb Standardized effect size % of scale
Total score T2, FACT-G ρ = 0.44  
Much better 73 (38) 28.7 (22.5)    
Minimally better 27 (14) 18.5 (21.1) 9.9 (9.1) 0.43 (0.40) 7.5 (6.9)
No change 43 (22) 8.6 (12.4)    
Minimally worse 26 (14) 6.9 (17.0)    
Much worse 13 (7) 12.9 (17.2)    
T3, FACT-G ρ = 0 0.47  
Much better 57 (31) 30.7 (22.6)    
Minimally better 35 (19) 21.2 (18.6) 6.1 (5.5) 0.42 (0.24) 4.7 (4.1)
No change 38 (21) 15.1 (14.5)    
Minimally worse 22 (13) 10.8 (18.0)    
Much worse 20 (12) 5.6 (20.4)    
FACT-Cog PCI T2, FACT-G ρ = −0.34  
Much better 73 (38) −16.5 (14.8)    
Minimally better 27 (14) −11.0 (14.5)    
No change 43 (22) −5.3 (10.6) 6.3 (4.4) 0.32 (0.30) 6.6 (6.1)
Minimally worse 26 (14) −10.5 (10.6)    
Much worse 13 (7) −18.0 (14.3)    
T3, FACT-G ρ = −0.38  
Much better 57 (31) −18.0 (14.4)    
Minimally better 35 (19) −13.5 (11.7)    
No change 38 (21) −10.4 (9.1) 3.1 (3.1) 0.21 (0.21) 4.4 (4.4)
Minimally worse 22 (13) −8.3 (12.1)    
Much worse 20 (12) −5.1 (12.0)    
  1. aChange in FACT-G < −7 (much worse), −7 to −4 (minimally worse), −3 to 3 (no change), 4 to 7 (minimally better), and > 7 (much better)
  2. b|Anchor min better – anchor no change| in mean change in FACT-Cog