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Journal of Patient-Reported Outcomes

Table 3 Anchor-based MCT estimates for improvement for the FACT-Cog total score (33 item) and FACT-Cog-PCI based on changes from baseline at post-intervention (T2) and six month follow-up (T3) using the primary anchor EORTC-CF. Results from sensitivity analysis shown in parenthesis in the last three columnsa. Correlations, ρ, are for the change in the FACT-Cog total score or PCI subscale and the change in anchor (categorized)

From: Important differences and meaningful changes for the Functional Assessment of Cancer Therapy-Cognitive Function (FACT-Cog)

FACT-Cog scale

Time

Anchor changeb

N (%)

Mean change in FACT-Cog (SD)

CID Estimatec

Standardized effect size

% of scale

Total score

T2

ρ = 0.55

 

Much better

92 (48)

27.8 (22.1)

   

Minimally better

50 (26)

15.1 (15.3)

   

No change

39 (20)

3.8 (13.9)

11.3 (10.8)

0.49 (0.47)

8.6 (8.0)

Minimally worse

10 (5)

5 (15.6)

   

Much worse

1 (0.5)

12 (−)

   

T3

ρ = 0.61

 

Much better

85 (47)

29.1 (20.7)

   

Minimally better

56 (31)

15.8 (15.1)

   

No change

35 (19)

7.1 (14.6)

8.8 (8.1)

0.38 (0.36)

6.6 (6.1)

Minimally worse

6 (3)

−14.7 (14.0)

   

Much worse

1 (0.6)

7 (−)

   

FACT-Cog PCI

T2

ρ = −0.49

 

Much better

92 (48)

−16.9 (13.7)

   

Minimally better

50 (26)

−9.8 (9.9)

   

No change

39 (20)

−2.4 (9.8)

7.4 (6.9)

0.50 (0.47)

10.3 (9.7)

Minimally worse

10

−4.8 (11.8)

   

Much worse

1

−8.0 (−)

   

T3

ρ = −0.54

 

Much better

85 (47)

−17.9 (12.7)

   

Minimally better

56 (31)

−10.1 (10.1)

   

No change

35 (19)

−5.5 (9.6)

4.6 (6.5)

0.31 (0.44)

6.4 (9.1)

Minimally worse

6 (3)

4.8 (8.7)

   

Much worse

1 (0.6)

−4.0 (−)

   
  1. aSensitivity analysis using 25 multiple imputed datasets
  2. bChange in EORTC-CF < −16.67 (much worse), −16.67 (minimally worse), 0 (no change), 16.67(minimally better), and > 16.67 (much better)
  3. c|Anchor min better – anchor no change| in mean change in FACT-Cog
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