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Table 3 Anchor-based MCT estimates for improvement for the FACT-Cog total score (33 item) and FACT-Cog-PCI based on changes from baseline at post-intervention (T2) and six month follow-up (T3) using the primary anchor EORTC-CF. Results from sensitivity analysis shown in parenthesis in the last three columnsa. Correlations, ρ, are for the change in the FACT-Cog total score or PCI subscale and the change in anchor (categorized)

From: Important differences and meaningful changes for the Functional Assessment of Cancer Therapy-Cognitive Function (FACT-Cog)

FACT-Cog scale Time Anchor changeb N (%) Mean change in FACT-Cog (SD) CID Estimatec Standardized effect size % of scale
Total score T2 ρ = 0.55  
Much better 92 (48) 27.8 (22.1)    
Minimally better 50 (26) 15.1 (15.3)    
No change 39 (20) 3.8 (13.9) 11.3 (10.8) 0.49 (0.47) 8.6 (8.0)
Minimally worse 10 (5) 5 (15.6)    
Much worse 1 (0.5) 12 (−)    
T3 ρ = 0.61  
Much better 85 (47) 29.1 (20.7)    
Minimally better 56 (31) 15.8 (15.1)    
No change 35 (19) 7.1 (14.6) 8.8 (8.1) 0.38 (0.36) 6.6 (6.1)
Minimally worse 6 (3) −14.7 (14.0)    
Much worse 1 (0.6) 7 (−)    
FACT-Cog PCI T2 ρ = −0.49  
Much better 92 (48) −16.9 (13.7)    
Minimally better 50 (26) −9.8 (9.9)    
No change 39 (20) −2.4 (9.8) 7.4 (6.9) 0.50 (0.47) 10.3 (9.7)
Minimally worse 10 −4.8 (11.8)    
Much worse 1 −8.0 (−)    
T3 ρ = −0.54  
Much better 85 (47) −17.9 (12.7)    
Minimally better 56 (31) −10.1 (10.1)    
No change 35 (19) −5.5 (9.6) 4.6 (6.5) 0.31 (0.44) 6.4 (9.1)
Minimally worse 6 (3) 4.8 (8.7)    
Much worse 1 (0.6) −4.0 (−)    
  1. aSensitivity analysis using 25 multiple imputed datasets
  2. bChange in EORTC-CF < −16.67 (much worse), −16.67 (minimally worse), 0 (no change), 16.67(minimally better), and > 16.67 (much better)
  3. c|Anchor min better – anchor no change| in mean change in FACT-Cog