Table 4 Baseline comorbidities and associated ICD-9-CM codes

hypertension

B-blockers, diuretics, Ca-channel blockers, ACE-I, ARBs

4011, 4019, 4010, 40,200, 40,201, 40,210, 40,211, 40,290, 40,291, 4030, 40,300, 40,301, 4031, 40,310, 40,311, 4039, 40,390, 40,391, 4040, 40,400, 40,401, 40,402, 40,403, 4041, 40,410, 40,411, 40,412, 40,413, 4049, 40,490, 40,491, 40,492, 40,493, 40,501, 40,509, 40,511, 40,519, 40,591, 40,599, 4372

coronary artery disease

Aspirin, ranolazine,

4110, 4111, 4118, 41,181, 41,189, 412, 4130, 4131, 4139, 4140, 41,400, 41,401, 41,406, 4142, 4143, 4144, 4148, 4149, V4581, V4582

congestive heart failure

B-blockers, diuretics, Ca-channel blockers, ACE-I, ARBs

39,891, 4280, 4281, 42,820, 42,821, 42,822, 42,823, 42,830, 42,831, 42,832, 42,833, 42,840, 42,841, 42,842, 42,843, 4289

atrial fibrillation

B-blockers, warfarin, Factor-X inhibitors

42,731, 42,732

chronic obstructive pulmonary disease

SABAs, LABAs, anticholinergics, inhaled corticosteroids

490, 4910, 4911, 4912, 49,120, 49,121, 49,122, 4918, 4919, 4920, 4928, 494, 4940, 4941, 496

asthma

SABA, inhaled corticosteroids, anticholinergics

49,300, 49,301, 49,302, 49,310, 49,311, 49,312, 49,320, 49,321, 49,322, 49,381, 49,382, 49,390, 49,391, 49,392

gastroesophageal reflux disease

H-1 receptor blockers, proton pump inhibitors

53,081

anemia

Folic acid, Iron, B-12, erythropoietin

2800, 2801, 2808, 2809, 2810, 2811, 2812, 2813, 2814, 2818, 2819, 2820, 2821, 2822, 2823, 2824, 28,240, 28,243, 28,244, 28,245, 28,246, 28,247, 28,249, 2827, 2828, 2829, 2830, 2831, 28,310, 28,311, 28,319, 2832, 2839, 2840, 28,401, 28,409, 2841, 28,412, 28,419, 2842, 2848, 28,481, 28,489, 2849, 2850, 28,521, 28,529, 2858, 2859, 2851

hypothyroidism

Levothyroxine, liothyronine

2449

diabetes mellitus, type 2

Oral antidiabetic medications, insulin

24,900, 25,000, 25,001, 7902, 79,021, 79,022, 79,029, 7915, 7916, V4585, V5391, V6546, 24,901, 24,910, 24,911, 24,920, 24,921, 24,930, 24,931, 24,940, 24,941, 24,950, 24,951, 24,960, 24,961, 24,970, 24,971, 24,980, 24,981, 24,990, 24,991, 25,002, 25,003, 25,010, 25,011, 25,012, 25,013, 25,020, 25,021, 25,022, 25,023, 25,030, 25,031, 25,032, 25,033, 25,040, 25,041, 25,042, 25,043, 25,050, 25,051, 25,052, 25,053, 25,060, 25,061, 25,062, 25,063, 25,070, 25,071, 25,072, 25,073, 25,080, 25,081, 25,082, 25,083, 25,090, 25,091, 25,092, 25,093

Hyperlipidemia, dyslipidemia, hypercholesterolemia

Statins, fibrates, niacin, cholystyramine

2720, 2721, 2722, 2723, 2724, 2720, 2721, 2722, 2723, 2724

allergic rhinitis

Intranasal corticosteroids, H1- blockers

4772, 4778, 4779

chronic kidney disease

ACE-I, ARBs

585, 5851, 5852, 5853, 5854, 5855, 5856, 5859, 7925, V420, V451, V4511, V4512, V560, V561, V562, V5631, V5632, V568

seizure disorder

Anti-epileptic medication

3450, 34,500, 34,501, 3451, 34,510, 34,511, 3452, 3453, 3454, 34,540, 34,541, 3455, 34,550, 34,551, 3456, 34,560, 34,561, 3457, 34,570, 34,571, 3458, 34,580, 34,581, 3459, 34,590, 34,591, 7803, 78,031, 78,032, 78,033, 78,039

depression

SSRi, tricyclic antidepressants

311

anxiety

SSRi, tricyclic antidepressants, benzodiazepines

29,384, 30,000, 30,001, 30,002, 30,009, 30,010, 30,020, 30,021, 30,022, 30,023, 30,029, 3003, 3005, 30,089, 3009, 3080, 3081, 3082, 3083, 3084, 3089

osteoarthritis

APAP, NSAIDS, opioids

71,500, 71,504, 71,509, 71,510, 71,511, 71,512, 71,513, 71,514, 71,515, 71,516, 71,517, 71,518, 71,520, 71,521, 71,522, 71,523, 71,524, 71,525, 71,526, 71,527, 71,528, 71,530, 71,531, 71,532, 71,533, 71,534, 71,535, 71,536, 71,537, 71,538, 71,580, 71,589, 71,590, 71,591, 71,592, 71,593, 71,594, 71,595, 71,596, 71,597, 71,598, V134