| | Results for Best Model: Row 1 = Model coefficient values Row 2 = p-value |
|---|
Domain | Intercept | Treatment | Time | Baseline Score | Time-squared |
BPI Worst Pain | 0.52 (< 0.0001) | −0.10 (0.39) | 0.002 (0.78) | 0.42 (< 0.0001) | 0.0006 (0.001) |
FACT-P Trial Outcome Index | 32.86 (< 0.0001) | 1.78 (0.02) | −0.21 (< 0.0001) | 0.60 (< 0.0001) | N/A |
- Table shows the best model results for the BPI worst pain scores and FACT-P trial outcome index. We used linear mixed models with random effects for the slope and intercept, with a specified compound symmetric correlation structure to account for autocorrelation of serial measures within patients. For each outcome, we examined whether scores differed over time by arm using a treatment by time interaction (both linear and quadratic); if no interaction as present, we modeled time as both linear and quadratic. Best model fit was determined as shown in Additional file 1: Table S1
