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Table 2 Best Model Results for BPI Worst Pain and FACT-P Trial Outcome Index

From: Patient-reported outcomes for patients with metastatic castration-resistant prostate cancer receiving docetaxel and Atrasentan versus docetaxel and placebo in a randomized phase III clinical trial (SWOG S0421)

  Results for Best Model: Row 1 = Model coefficient values Row 2 = p-value
Domain Intercept Treatment Time Baseline Score Time-squared
BPI Worst Pain 0.52 (< 0.0001) −0.10 (0.39) 0.002 (0.78) 0.42 (< 0.0001) 0.0006 (0.001)
FACT-P Trial Outcome Index 32.86 (< 0.0001) 1.78 (0.02) −0.21 (< 0.0001) 0.60 (< 0.0001) N/A
  1. Table shows the best model results for the BPI worst pain scores and FACT-P trial outcome index. We used linear mixed models with random effects for the slope and intercept, with a specified compound symmetric correlation structure to account for autocorrelation of serial measures within patients. For each outcome, we examined whether scores differed over time by arm using a treatment by time interaction (both linear and quadratic); if no interaction as present, we modeled time as both linear and quadratic. Best model fit was determined as shown in Additional file 1: Table S1