Development and validation of the Ulcerative Colitis patient-reported outcomes signs and symptoms (UC-pro/SS) diary

Journal of Patient-Reported Outcomes

Table 3 Correlations between UC-PRO/SS Scores and Other Clinical Variables^a,b

Clinical Variable	Bowel Signs and Symptoms Rating (p value)	Abdominal Symptoms Rating (p value)
Clinician Ratings:
Partial Mayo Score	0.79 (< 0.0001)	0.45 (< 0.0001)
Clinician Global Rating of Disease Severity	0.69 (< 0.0001)	0.44 (< 0.0001)
Patient Ratings:
Patient Global Rating of Disease Severity	0.67 (< 0.0001)	0.52 (< 0.0001)
IBDQ
Total score	−0.70 (< 0.0001)	− 0.61 (< 0.0001)
Bowel systems	− 0.73 (< 0.0001)	− 0.65 (< 0.0001)
Emotional health	− 0.61 (< 0.0001)	− 0.53 (< 0.0001)
Systemic systems	− 0.51 (< 0.0001)	−0.53 (< 0.0001)
Social function	−0.62 (< 0.0001)	−0.49 (< 0.0001)
WPAI-SHP
Absenteeism	0.35 (< 0.0001)	0.22 (0.0107)
Presenteeism	0.63 (< 0.0001)	0.45 (< 0.0001)
Work productivity loss	0.63 (< 0.0001)	0.46 (< 0.0001)
Activity impairment	0.63 (< 0.0001)	0.47 (< 0.0001)
PROMIS
Global physical health	−0.21 (0.0031)	− 0.28 (< 0.0001)
Global mental health	−0.28 (< 0.0001)	− 0.33 (< 0.0001)
General health	−0.26 (0.0003)	− 0.33 (< 0.0001)
Satisfaction with social role	− 0.25 (0.0006)	−0.28 (< 0.0001)
BPI–Worst Pain	0.57 (< 0.0001)	0.64 (< 0.0001)

Abbreviations: BM bowel movement, BPI brief pain inventory, IBDQ Inflammatory Bowel Disease Questionnaire, PROMIS Patient Reported Outcomes Measurement Information System, UC-PRO/GI-SS Ulcerative Colitis Patient-reported Outcomes Gastrointestinal Signs and Symptoms Scale, WPAI-SHP Work Productivity and Activity Impairment–Specific Health Problems
^aSpearman’s correlation coefficients
^bSeven-day average scores used