| |
Baseline
|
Week 3
|
Week 8
|
Month 12
|
Post hoc comparisons (Bonferroni-adjusted P [α/4])
|
---|
N
|
LS Mean
|
SE
|
LS Mean
|
SE
|
LS Mean
|
SE
|
LS Mean
|
SE
|
P
|
Baseline vs. Week 3
|
Baseline vs. Week 8
|
Baseline vs. Month 12
|
Week 8 vs. Month 12
|
---|
Absenteeism
|
260
|
12.1
|
1.60
|
5.2
|
1.19
|
2.6
|
0.78
|
3.8
|
0.93
|
‡
|
‡
|
‡
|
‡
|
1.0000
|
Presenteeism
|
264
|
32.6
|
1.62
|
16.3
|
1.17
|
9.6
|
0.96
|
13.4
|
1.44
|
‡
|
‡
|
‡
|
‡
|
0.1015
|
Overall work impairment
|
260
|
38.9
|
1.92
|
20.1
|
1.54
|
11.5
|
1.24
|
15.7
|
1.72
|
‡
|
‡
|
‡
|
‡
|
0.2222
|
Activity impairment
|
395
|
38.9
|
1.36
|
20.6
|
1.05
|
10.7
|
0.78
|
15.4
|
1.17
|
‡
|
‡
|
‡
|
‡
|
†
|
- LS least squares, SE standard error, WPAI:UC Work Productivity and Activity Impairment questionnaire for ulcerative colitis
- Findings for each outcome are based on mixed-effects models for repeated measures with subject as a random effect and visit as a fixed effect
- Week 8 includes early withdrawal visits during the acute phase. “Month 12” includes early withdrawal visits during the maintenance phase
- †P < 0.01, ‡P < 0.001