| | |
Baseline
|
Week 3
|
Week 8
|
Post hoc comparisons (Bonferroni-adjusted P [α/3])
|
|---|
|
N
|
LS Mean
|
SE
|
LS Mean
|
SE
|
LS Mean
|
SD
|
P
|
Baseline vs. Week 3
|
Baseline vs. Week 8
|
Week 3 vs. Week 8
|
|---|
|
Absenteeism
|
367
|
13.0
|
1.35
|
6.6
|
1.03
|
4.5
|
0.80
|
‡
|
‡
|
‡
|
0.1341
|
|
Presenteeism
|
376
|
35.9
|
1.37
|
21.2
|
1.15
|
16.7
|
1.19
|
‡
|
‡
|
‡
|
‡
|
|
Overall work impairment
|
365
|
42.0
|
1.60
|
25.4
|
1.42
|
19.8
|
1.39
|
‡
|
‡
|
‡
|
‡
|
|
Activity impairment
|
579
|
41.5
|
1.12
|
26.2
|
1.02
|
19.3
|
1.02
|
‡
|
‡
|
‡
|
‡
|
- LS least squares, SE standard error, WPAI:UC Work Productivity and Activity Impairment questionnaire for ulcerative colitis
- Findings for each outcome are based on mixed-effects models for repeated measures with subject as a random effect and visit as a fixed effect
- Week 8 includes early withdrawal visits during the acute phase
- ‡P < 0.001
