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Table 1 Patient demographics and clinical characteristics

From: Understanding and measuring symptoms and health status in asthma COPD overlap: content validity of the EXACT and SGRQ

  Patients with ACO (n = 20) Patients with COPD (n = 10) Total (n = 30)
Demographics
Age (years), mean (range) 58.5 (45–72) 64.4 (52–79) 60.5 (45–79)
Gender, % (n)
 Male 65 (13) 60 (6) 63 (19)
Ethnicity, % (n)
 Not Hispanic/Latino 95 (19) 90 (9) 93 (28)
Race, % (n)
 African American/African 10 (2) 30 (3) 17 (5)
 White – Arabic/North African 5 (1) 3 (1)
 White – White/Caucasian/European 80 (16) 60 (6) 73 (22)
 Other: White 10 (1) 3 (1)
 No response 5 (1) 3 (1)
Education, % (n)a
 Some high school 15 (3) 20 (2) 17 (5)
 High school diploma/GED 20 (4) 50 (5) 30 (9)
 Some years of college 35 (7) 23 (7)
 Certificate program 10 (2) 10 (1) 10 (3)
 University/college degree (2 or 4 year) 20 (4) 20 (2) 20 (6)
 Vocational training 10 (2) 7 (2)
Work status, % (n)a
 Working full time 55 (11) 10 (1) 40 (12)
 Looking for work 10 (1) 3 (1)
 Full-time homemaker 5 (1) 3 (1)
 Not working due to respiratory condition 15 (3) 10 (1) 13 (4)
 Retired 20 (4) 50 (5) 30 (9)
 Other: disabled or odd jobs around neighborhood 5 (1) 20 (2) 10 (3)
General health, % (n)
 Very good 10 (2) 10 (1) 10 (3)
 Good 55 (11) 50 (5) 53 (16)
 Fair 30 (6) 30 (3) 30 (9)
 Poor 5 (1) 10 (1) 7 (2)
MMRC dyspnea scale, % (n)a
 0 50 (10) 30 (3) 43 (13)
 1 55 (11) 70 (7) 60 (18)
 2 20 (4) 30 (3) 23 (7)
 3 15 (3) 20 (2) 17 (5)
Clinical characteristics
Primary disease, % (n)
 Asthma 45 (9) 30 (9)
 COPD type: Chronic bronchitis 55 (11) 100 (10) 70 (21)
 COPD type: Emphysema 10 (2) 50 (5) 23 (7)
First use of a maintenance therapy inhaler (years)
 Mean (range) 40.5 (14–64) 42 (8–60) 42 (8–64)
Asthma diagnosis, % (n)
 Yes 60 (12) 40 (4) 80 (16)
 Mean (range) age when first diagnosed 23 (5–62) 30.5 (1–57) 25 (1–62)
COPD diagnosis, % (n)
 Yes 65 (13) 100 (10) 77 (23)
 Mean (range) age when first diagnosed 49 (25–63) 52.5 (38–71) 50 (25–71)
Smoking history, % (n)
 Never smoked 25 (5) 16 (5)
 Current smoker 25 (5) 60 (6) 37 (11)
 Former smoker 50 (10) 40 (4) 47 (14)
Smoking history, pack years
 Mean (range) 35 (4–92)b 56 (33–90)c 43 (4–92)
Exacerbations that required corticosteroids
 In the last 12 months, n 10 1 11
 Mean (range) 0.9 (0–4) 0.1 (0–1) 0.6 (0–4)
 In the last 3 months (n) 3 0 3
 Mean (range) 0.15 (0–1) 0.1 (0–1)
Exacerbations that required hospitalization
 In the last 12 months (n) 2 2 4
 In the last 3 months (n) 0 1 1
Lung function FEV1 (% predicted), mean (range) 54 (1.6–68) 50 (1–79) 53 (1–79)
Reversibility (L), mean (range)
 Pre-albuterol lung function (L in FEV1) 1.7 (1.1–2.7) 1.7 (1.1–2.6) 1.7 (1.1–2.7)
 Post-albuterol lung function (L in FEV1) 2.1 (1.3–3.1) 1.7 (0.8–2.5) 1.9 (0.8–3.1)
 Percent change 19.2 (11.5–38.2) 0.2 (−23.1–7.8) 12.8 (−23.1–38.2)
Clinician rated severity of COPD, % (n)
 Moderate 100 (20) 70 (7) 90 (27)
 Severe 30 (3) 10 (3)
  1. ACO asthma-COPD overlap, COPD chronic obstructive disease, FEV1 forced expiratory volume in 1 s, GED General Educational Development, MMRC Modified Medical Research Council
  2. aMore than one option could be selected
  3. bn = 15 (current and former smokers)
  4. cn = 10 (current and former smokers)