Development of a novel observer-reported outcome measure for the assessment of Respiratory Syncytial Virus (RSV) infection symptoms in pediatric clinical trials

Journal of Patient-Reported Outcomes

Table 1 Respiratory Syncytial Virus Symptoms Assessed Using Observer-Reported and Clinician-Reported Measures

RSV Symptom Measure	Wheezing/Auscultatory breath sounds	Cough	Retractions/Chest recessions	Rhinorrhea/Nasal discharge/Runny nose	Respiratory rate/Rapid breathing/Tachypnea	Trouble breathing/Short of breath	Fever	Skin color/Cyanosis	General Condition/ Appearance	Not sleeping well/Sleeping less than normal	Eating less than normal/Poor appetite	Sneeze	Stopped or plugged nose/Nasal congestion	Duration of illness	Hoarseness	Apnea
Observer-reported
BCD	●	●				●
CARIFS		●		●			●			●
WURSS		●		●							●	●	●
Clinician-reported
Gern score	●	●	●	●	●		●	●						●	●	●
RDAI	●		●
Wang Clinical Severity Score	●		●		●				●
Clinical Scoring System	●		●		●			●	●
Respiratory Symptom Log	●	●		●		●
LRI Score									●

BCD Bronchiolitis Caregiver Diary, CARIFS Canadian Acute Respiratory Illness and Flu Scale, LRI Lower Respiratory Infection/Illness, RDAI Respiratory Distress Assessment Instrument, RSV respiratory syncytial virus; WURSS Wisconsin Upper Respiratory Symptom Survey