Table 9 Anchor-based assessment of meaningful change for NVSA© scores with sPGA
Number of Days of Vomiting or Nausea | Number of Episodes of Vomiting | Mean Severity of Nausea | |
|---|---|---|---|
sPGA Score Used | n, mean Δ between weeks, SE Δ | n, mean Δ between weeks, SE Δ | n, mean Δ between weeks, SE Δ |
Minimally Worsen | Minimally Worsen | Minimally Worsen | |
Week 2-Week 1 | (n = 7) 0.68 (0.50) | (n = 7) 0.31 (0.16) | |
Week 3-Week 2 | (n = 7) 0.58 (0.86) | (n = 7) −0.39 (0.78) | |
Week 4-Week 3 | |||
Week 5-Week 4 | |||
Week 6-Week 5 | (n = 8) 0.59 (0.57) | (n = 6) 1.42 (0.92) | (n = 8) 0.23 (0.10) |
Week 7-Week 6 | (n = 6) 0.17 (0.70) | (n = 6) 0.48 (0.34) | |
Week 8-Week 7 | |||
Mean | 0.50 | 1.42 | 0.16 |
Median | 0.58 | 1.42 | 0.27 |
Minimally Improve | Minimally Improve | Minimally Improve | |
Week 2-Week 1 | (n = 7) −1.80 (0.92) | (n = 7) −1.02 (0.47) | |
Week 3-Week 2 | (n = 7) 0.11 (0.84) | (n = 6) −1.03 (0.35) | (n = 7) −0.46 (0.24) |
Week 4-Week 3 | (n = 6) − 1.07 (0.52) | (n = 6) − 0.15 (0.16) | |
Week 5-Week 4 | |||
Week 6-Week 5 | |||
Week 7-Week 6 | (n = 7) − 0.68 (0.68) | (n = 7) −1.64 (1.02) | (n = 7) − 0.22 (0.21) |
Week 8-Week 7 | |||
Mean | −0.86 | −1.33 | −0.46 |
Median | −0.87 | −1.33 | −0.34 |