Model 1a-1d Individual PROs
|
1a) Pain interferencea
|
−1.30 (0.05)
|
< 0.0001
|
−1.17 (0.04)
|
< 0.0001
|
−1.53 (0.10)
|
< 0.0001
|
1b) Morning stiffness
|
>15 min
|
−19.92 (0.91)
|
< 0.0001
|
−16.77 (1.23)
|
< 0.0001
|
−25.65 (2.05)
|
< 0.0001
|
≤ 15 min
|
reference
|
reference
|
reference
|
1c) Serious medication side effect
|
Any
|
−12.54 (3.77)
|
0.0009
|
−10.82 (3.54)
|
0.0023
|
−15.68 (4.75)
|
0.0010
|
None
|
reference
|
reference
|
reference
|
1d) Methotrexate status
|
With methotrexate intolerance
|
−3.66 (1.42)
|
0.0100
|
−3.96 (0.77)
|
< 0.0001
|
−3.15 (3.20)
|
0.3239
|
On methotrexate without intolerance
|
4.89 (1.24)
|
< 0.0001
|
4.84 (1.43)
|
0.0007
|
4.91 (2.49)
|
0.0487
|
Not on methotrexate
|
reference
|
reference
|
reference
|
Model 2 Disease Burden PROs
|
Pain interferencea
|
−1.27 (0.05)
|
< 0.0001
|
−1.17 (0.05)
|
< 0.0001
|
−1.45 (0.09)
|
< 0.0001
|
Morning stiffness
|
>15 min
|
−1.99 (0.50)
|
< 0.0001
|
−0.28 (0.92)
|
0.7611
|
−5.13 (1.81)
|
0.0046
|
≤ 15 min
|
reference
|
reference
|
reference
|
Model 3 Treatment Burden PROs
|
Serious medication side effect
|
Any
|
−11.68 (3.77)
|
0.0020
|
−9.87 (3.70)
|
0.0076
|
−15.10 (4.56)
|
0.0009
|
None
|
reference
|
reference
|
reference
|
Methotrexate status
|
With methotrexate intolerance
|
−2.13 (1.34)
|
0.1121
|
−2.66 (0.30)
|
< 0.0001
|
−1.15 (3.46)
|
0.7406
|
On methotrexate without intolerance
|
3.89 (1.64)
|
0.0175
|
4.01 (2.14)
|
0.0607
|
3.73 (1.67)
|
0.0257
|
Not on methotrexate
|
reference
|
reference
|
reference
|
Model 4 All PROs
|
Pain interferencea
|
−1.21 (0.07)
|
< 0.0001
|
−1.12 (0.07)
|
< 0.0001
|
−1.38 (0.08)
|
< 0.0001
|
Morning stiffness
|
>15 min
|
−2.39 (0.17)
|
< 0.0001
|
−0.73 (0.80)
|
0.3628
|
−5.48 (1.88)
|
0.0035
|
≤ 15 min
|
reference
|
reference
|
reference
|
Serious medication side effect
|
Any
|
−3.64 (1.89)
|
0.0548
|
−2.67 (2.18)
|
0.2201
|
−5.47 (2.28)
|
0.0163
|
None
|
reference
|
reference
|
reference
|
Methotrexate status
|
With methotrexate intolerance
|
−3.24 (0.92)
|
0.0004
|
−3.57 (1.06)
|
0.0008
|
−2.55 (2.48)
|
0.3031
|
On methotrexate without intolerance
|
1.47 (0.39)
|
0.0001
|
1.83 (0.73)
|
0.0119
|
0.94 (2.11)
|
0.6540
|
Not on methotrexate
|
reference
|
reference
|
reference
|