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Journal of Patient-Reported Outcomes

Table 5 Estimates of meaningful change in DSQ score in patients with EoE at baseline and from baseline to week 12 of the treatment period

From: Psychometric validation of the Dysphagia Symptom Questionnaire in patients with eosinophilic esophagitis treated with budesonide oral suspension

 

Mean baseline DSQ score (absolute)

Mean baseline DSQ score (percentage)

Distribution-baseda

n

Mean

SD

½ SD

n

Mean (%)

SD

½ SD

 

93

29.9

14.8

7.4

93

35.4

17.7

8.9

 

Mean change in DSQ score (absolute)

Mean change in DSQ score (percentage)

Anchor-basedb

n

Mean change

SD

½ SD

n

Mean change (%)

SD

½ SD

 Much better

20

−20.0

14.5

–

20

−75.4

25.1

–

 Betterc

23

−13.5

12.7

–

23

−55.4

41.2

–

 A little betterd

24

−6.5

8.1

–

24

−27.4

43.6

–

 No change

14

−5.4

9.0

–

14

−15.4

37.6

–

 A little worse

6

−3.6

7.7

–

6

−12.7

49.7

–

 Worse

2

−1.6

4.0

–

2

−2.8

8.0

–

 Much worse

1

28.0

–

–

1

100.0

–

–

  1. CID clinically important difference, DSQ Dysphagia Symptom Questionnaire, EoE eosinophilic esophagitis, MCID minimal clinically important difference, MID minimally important difference, PGIC Patient Global Impression of Change, SD standard deviation
  2. aDistribution-based estimates were driven by the overall distribution of DSQ scores at baseline (visit 2)
  3. bAnchor-based estimates were driven by the mean change in DSQ scores from baseline (visit 2) to week 12 in patients by their PGIC groupings
  4. cEstimate for CID
  5. dEstimate for MCID
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