Real-world use and clinical impact of an electronic patient-reported outcome tool in patients with solid tumors treated with immuno-oncology therapy

Dickson, Natalie R; Beauchamp, Karen D; Perry, Toni S; Roush, Ashley; Goldschmidt, Deborah; Edwards, Marie Louise; Blakely, L Johnetta

doi:10.1186/s41687-024-00700-4

Journal of Patient-Reported Outcomes

Table 4 Use of ePRO platform in ePRO users subgroup

From: Real-world use and clinical impact of an electronic patient-reported outcome tool in patients with solid tumors treated with immuno-oncology therapy

Parameter	Months 1–3 after index date^a (n = 259)	Months 4–6 after index date^a (n = 120)
Questionnaires
Total number of questionnaires sent per patient
Mean (SD)	6.5 (3.0)	6.5 (3.3)
Median	6.0	6.0
Total number of questionnaires answered per patient
Mean (SD)	3.7 (2.3)	3.2 (2.1)
Median	4.0	3.0
Answered by the patient
Mean (SD)	3.1 (2.1)	2.5 (2.1)
Median	3.0	2.0
Answered by the caregiver
Mean (SD)	0.3 (0.9)	0.2 (1.0)
Median	0.0	0.0
Answered by the clinic
Mean (SD)	0.3 (0.7)	0.5 (1.0)
Median	0.0	0.0
Total number of questionnaires expired per patient
Mean (SD)	2.8 (2.4)	3.3 (2.5)
Median	2.0	3.0
Patient/caregiver-reported symptoms
Number of symptoms per patient
Mean (SD)	0.7 (1.4)	0.4 (1.1)
Median	0.0	0.0
Number of reported symptoms, n (%)
0	189 (73.0)	99 (82.5)
1–2	35 (13.5)	12 (10.0)
3–4	30 (11.6)	7 (5.8)
5–6	4 (1.5)	1 (0.8)
7+	1 (0.4)	1 (0.8)
Number of severe^b symptoms per patient
Mean (SD)	0.1 (0.4)	0.0 (0.2)
Median	0.0	0.0
Number of reported severe^b symptoms, n (%)
0	241 (93.1)	116 (96.7)
1–2	16 (6.2)	4 (3.3)
3–4	2 (0.8)	0 (0.0)
5–6	0 (0.0)	0 (0.0)
7+	0 (0.0)	0 (0.0)
Symptom alerts
Proportion of patients with any alerts, n (%)	29 (11.2)	9 (7.5)
Number of alerts per patient
Mean (SD)	0.2 (0.6)	0.1 (0.4)
Median	0.0	0.0
Proportion of patients in each outcome category,^c,d n (%)
Provider consulted	6 (20.7)	3 (33.3)
Hospital admission	1 (3.4)	0 (0.0)
Resolved on phone/message	26 (89.7)	5 (55.6)
Scheduled visit	3 (10.3)	1 (11.1)
Follow-up required^e	4 (13.8)	2 (22.2)
Non-clinical call/message	0 (0.0)	0 (0.0)
No follow-up needed	0 (0.0)	0 (0.0)
Outcome per alert^f
Number of alerts	61	37
Proportion of alerts in each outcome category,^c n (%)
Provider consulted	9 (14.8)	3 (8.1)
Hospital admission	1 (1.6)	0 (0.0)
Resolved on phone/message	49 (80.3)	29 (78.4)
Scheduled visit	4 (6.6)	1 (2.7)
Follow-up required^e	10 (16.4)	3 (8.1)
Non-clinical call/message	1 (1.6)	3 (8.1)
No follow-up needed	0 (0.0)	0 (0.0)

^aMonth 1 was defined as starting on the index date; for the 3-month period analyses, results were reported among ePRO users who were followed for the entirety of each assessment period
^bDegree of severity was reported by patients or caregivers via the ePRO platform. Of the 14 patient- or caregiver-reported symptoms, 11 could be reported as severe
^cEach alert may result in more than one outcome. The proportion of patients with any alerts in each outcome category was reported
^dDenominator is the number of patients with any alert
^e“Follow-up required” included the case outcome options of “additional follow-up required,” “needs follow-up,” and “left message.”
^fePRO users were not required to have complete follow-up in each time period assessed for alert outcomes
ePRO electronic patient-reported outcome; SD standard deviation

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