Table 2 Comparison of PROMIS physical function to other tests evaluating (physical) functioning in LOPD

6MWD (per 1-meter increment)

0 weeks (baseline)¹

0.06

(0.04, 0.07)

< 0.0001

0.04

(0.02, 0.07)

0.0006

Change from 0 to 52 weeks¹

0.09

(0.05, 0.12)

< 0.0001

0.08

(0.03, 0.12)

0.0016

All measurements²

0.06

(0.05, 0.07)

< 0.0001

0.05

(0.03, 0.06)

< 0.0001

FVC (per 1% increment in predicted value)

0 weeks (baseline)¹

0.20

(0.09, 0.30)

0.0004

0.10

(-0.04, 0.24)

0.1719

Change from 0 to 52 weeks¹

0.05

(-0.21, 0.31)

0.7035

0.06

(-0.30, 0.42)

0.7522

All measurements²

0.14

(0.07, 0.21)

0.0001

0.08

(0.00, 0.17)

0.0490

MMT of lower extremities (per 1-point increment)

0 weeks (baseline)¹

0.96

(0.61, 1.30)

< 0.0001

0.67

(0.23, 1.11)

0.0034

Change from 0 to 52 weeks¹

0.15

(-0.33, 0.63)

0.5349

0.08

(-0.45 0.61)

0.7626

All measurements²

0.26

(0.10, 0.43)

0.0023

0.11

(-0.07 0.29)

0.2401

GSGC test score (per 1-point increment)

0 weeks (baseline)¹

-1.31

(-1.72, -0.90)

< 0.0001

-0.78

(-1.47, -0.09)

0.0278

Change from 0 to 52 weeks¹

-0.28

(-1.01, 0.45)

0.4482

-0.30

(-1.30, 0.70)

0.5527

All measurements²

-0.48

(-0.74, -0.21)

0.0005

-0.19

(-0.52 0.14)

0.2489

R-PAct (per 1-point increment)

0 weeks (baseline)¹

1.81

(1.57, 2.04)

< 0.0001

1.72

(1.36, 2.08)

< 0.0001

Change from 0 to 52 weeks¹

1.07

(0.65, 1.50)

< 0.0001

1.03

(0.52, 1.53)

0.0001

All measurements²

1.19

(1.05, 1.34)

< 0.0001

1.23

(1.04, 1.41)

< 0.0001