Table 1 Summary of outcome measurements collected in PROPEL
Outcome | Baseline | Week 12 | Week 26 | Week 38 | Week 52 | Δ baseline and week 52 |
|---|---|---|---|---|---|---|
PROMIS Physical Function short form 20a score | ||||||
N | 121 | 117 | 121 | 121 | 121 | 121 |
mean, SD | 67 (12) | 69 (14) | 69 (14) | 69 (14) | 69 (14) | 1 (9) |
median, range | 67 (37–97) | 70 (37–98) | 69 (32–99) | 70 (36–99) | 68 (36–99) | 0 (-30–30) |
6-minute walk distance in meters | ||||||
N | 122 | 122 | 122 | 122 | 122 | 122 |
mean, SD | 356 (114) | 367 (119) | 370 (123) | 370 (122) | 372 (127) | 17 (42) |
median, range | 363 (79–623) | 374 (101–619) | 378 (40–678) | 376 (77–634) | 378 (67–649) | 11 (-60–174) |
FVC % predicted | ||||||
N | 122 | 121 | 120 | 120 | 121 | 121 |
mean, SD | 70 (20) | 70 (21) | 69 (20) | 69 (20) | 69 (20) | -2 (6) |
median, range | 70 (31–133) | 69 (32–155) | 69 (32–148) | 68 (31–138) | 69 (28–137) | -1.5 (-20–14) |
MMT of lower extremities score | ||||||
N | 118 | 113 | 112 | 114 | 114 | 114 |
mean, SD | 28 (6) | 29 (6) | 29 (6) | 29 (6) | 29 (6) | 1 (3) |
median, range | 28 (14–40) | 28 (13–40) | 29 (13–40) | 29 (12–40) | 30 (10–40) | 1 (-10–18) |
GSGC score | ||||||
N | 106 | 100 | 100 | 100 | 102 | 102 |
mean, SD | 15 (5) | 14 (5) | 14 (5) | 14 (5) | 14 (5) | 0 (2) |
median, range | 16 (4–24) | 16 (4–23) | 16 (4–24) | 15 (4–24) | 16 (4–24) | 0 (-8–5) |
R-PAct score | ||||||
N | 102 | 102 | 102 | 102 | 102 | 102 |
mean, SD | 20 (6) | 21 (7) | 21 (6) | 20 (7) | 21 (7) | 0 (3) |
median, range | 20 (10–36) | 21 (8–36) | 19 (8–36) | 19 (9–36) | 19 (8–36) | 0 (-9–11) |