Meaningful score changes for SF-36v2, FACIT-fatigue, and RASIQ in rheumatoid arthritis

Rendas-Baum, Regina; Lin, Xiaochen; Kosinski, Mark; Bjorner, Jakob Bue; Bracher, Marguerite G.; Chen, Wen-Hung

doi:10.1186/s41687-024-00685-0

Journal of Patient-Reported Outcomes

Table 2 Anchor- and distribution-based estimates for the SF-36v2, FACIT-fatigue, and RASIQ

From: Meaningful score changes for SF-36v2, FACIT-fatigue, and RASIQ in rheumatoid arthritis

	Anchor-based WPMI estimates							Distribution-based estimates		Reliabilityⁱ
	Anchor	N	Mean	95% CI	SRM	Sensitivity	Specificity	0.5 SD	RCI(80)	Reliabilityⁱ
SF-36v2 scale (0–100 scoring)
PF	PtGA^a	120	24.5	21.1, 28.0	1.27	0.78	0.56	9.8	12.7	0.87
RP	PtGA^a	120	24.5	20.6, 28.5	1.37	0.77	0.58	9.1	10.7	0.89
BP	PtGA^a	120	25.4	21.9, 28.9	1.65	0.80	0.43	7.6	11.1	0.84
BP	PAIN^b	125	26.6	23.3, 29.9	1.73	0.87	0.47
GH	PtGA^a	120	13.6	10.8, 16.4	0.87	0.74	0.45	8.2	16.7	0.68
VT	PtGA^a	120	21.5	18.2, 24.8	1.30	0.75	0.50	8.3	13.1	0.81
	AN5^c	60	23.3	18.7, 28.0	1.41	0.71	0.55
SF	PtGA^a	120	20.5	16.3, 24.7	0.98	0.66	0.51	10.5	19.7	0.74
RE	PtGA^a	120	16.9	12.9, 21.0	0.70	0.68	0.45	12.4	12.1	0.93
MH	PtGA^a	120	14.3	11.3, 17.3	0.75	0.69	0.53	9.5	13.3	0.85
SF-36v2 summary (NBS scoring)
PCS	PtGA^a	120	9.7	8.3, 11.1	1.47	0.83	0.47	3.4	4.1	0.89
MCS	PtGA^a	120	7.6	5.8, 9.4	0.70	0.66	0.50	5.4	6.0	0.91
FACIT-Fatigue (0–52 scoring)
Fatigue	SF-36 PGIS^d	120	11.3	9.7, 12.9	1.15	0.81	0.52			0.92
	PtGA^a	80	9.7	8.1, 11.4	0.99	0.75	0.58	4.9	4.9
	VT03^e	74	11.1	9.4, 12.9	1.13	0.85	0.55
RASIQ (0–100 scoring)
Joint pain	SF-36 PGIS^d	66	-24.0	-28.4, -19.7	-1.34	0.73	0.56	9.1	-6.8	0.96
	PtGA^a	104	-31.0	-34.6, -27.5	-1.70	0.94	0.49
	PAIN^b	97	-32.7	-36.2, -29.3	-1.80	0.94	0.51
	BP01^f	71	-21.7	-25.4, -18.0	-1.21	0.84	0.58
Joint stiffness	PGIS^d	66	-23.3	-27.4, -19.1	-1.31	0.73	0.62	9.1	-13.1	0.84
	PtGA^a	104	-26.1	-29.8, -22.3	-1.44	0.83	0.47
Impact	SF-36 PGIS^d	66	-21.0	-24.5, -17.4	-1.35	0.89	0.48	7.8	-12.8	0.80
	PtGA^a	104	-21.1	-24.3, -17.9	-1.35	0.93	0.44
	AN2^g	70	-17.4	-20.7, -14.0	-1.12	0.85	0.57
	AN1^h	61	-17.8	-21.7, -13.8	-1.14	0.79	0.58

^a‘Considering all the ways your arthritis has affected you, how active do you feel your arthritis is…’. Improvement: a decline of 18 points or more
^b‘How much pain are you currently having because of your rheumatoid arthritis?’ Improvement: a decline of 20 points or more
^c‘I have energy’. Improvement: an increase of 1 point on a 5-point Likert scale
^d‘In general, would you say your health is…’. Improvement: an increase of 1 point on a 5-point Likert scale
^e‘How much of the time during the past 4 weeks did you feel worn out?’ Improvement: an increase of 1 point on a 5-point Likert scale
^f‘How much bodily pain have you had during the past 4 weeks?’ Improvement: an increase of 1 point on a 5-point Likert scale
^g‘I feel tired’. Improvement: an increase of 1 point on a 5-point Likert scale
^h‘I feel listless (washed out)’. Improvement: an increase of 1 point on a 5-point Likert scale
ⁱCronbach’s alpha, except for SF-36v2 summary scores (PCS, MCS), where reliability is estimated using a method that accounts for the reliability of each score as well as covariances among the scores
AN: anchor; BP, bodily pain; CI: confidence interval; FACIT-Fatigue: Functional Assessment of Chronic Illness Therapy-Fatigue; GH: general health perceptions; MCS: Mental Component Summary; MH: role limitations due to emotional problems; PAIN: Patient’s Assessment of Arthritis Pain; PCS: Physical Component Summary; PF: physical functioning; PGIS: Patient’s Global Impression of Status; PtGA: Patient’s Global Assessment of Disease Activity; RASIQ: Rheumatoid Arthritis Symptoms and Impact Questionnaire; RCI(80): reliable change index based on 80% confidence interval; RE: role limitations due to emotional problems; RP: role limitations due to physical health; SD: standard deviation; SF: social functioning; SF-36v2: Short-Form 36 Health Survey version 2; SRM: standardized response mean; VT: vitality; WPMI: within-patient meaningful improvement

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