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Table 1 Interview participant characteristics

From: Use of the National Cancer Institute Patient-Reported Outcomes version of the Common Terminology Criteria for Adverse Events to assess treatment tolerability in pulmonary arterial hypertension: qualitative patient research findings in current and former users of oral selexipag

Characteristic

Total sample (N = 20)

Age (years), mean (SD), range

50 (11), 24–68

Gender, n (%)

 

Female

15 (75)

Male

5 (25)

Race/ethnicity,* n (%)

 

White

15 (75)

African American or Black

3 (15)

Asian

1 (5)

Hispanic, Latin American, or Latinx

1 (5)

Education, n (%)

 

Less than high school

1 (5)

High school diploma or equivalent (e.g., GED)

4 (20)

Technical school or associate’s degree

3 (15)

Some college

4 (20)

College degree (bachelor’s degree)

6 (30)

Professional or advanced degree

2 (10)

Employment status, n (%)

 

Full time

6 (30)

Part time

3 (15)

Self employed

2 (10)

Unemployed and not looking for work

5 (25)

Retired

4 (20)

Currently taking selexipag, n (%)

 

Yes

15 (75)

No longer taking

5 (25)

WHO Functional Class, † n (%)

 

I

2 (10)

II

10 (50)

III

7 (35)

IV

1 (5)

Severity of current PAH symptoms (self-report), n (%)

 

Mild

6 (30)

Moderate

12 (60)

Severe

2 (10)

PAH diagnosis year, mean (SD), range

2015 (4.6), 2004–2021

Current PAH treatment regimen, n (%)

 

Selexipag monotherapy

0

Selexipag and a medication targeting one other pathway (double therapy)

3 (15)

Selexipag and medications targeting two other pathways (triple therapy)

12 (60)

Not currently taking selexipag

5 (25)

Current PAH medication(s),*‡ n (%)

 

Nitric oxide pathway

 

 Tadalafil

8 (40)

 Sildenafil

7 (35)

 Riociguat

5 (25)

Endothelin receptor antagonists

 

 Macitentan

10 (50)

 Ambrisentan

5 (25)

 Bosentan

1 (5)

Drugs acting on the prostacyclin pathway

 

 Selexipag

15 (75)

 Treprostinil (intravenous or subcutaneous)

3 (15)

 Treprostinil (inhaled)

2 (10)

  1. GED: General Educational Development; PAH: pulmonary arterial hypertension; SD: standard deviation; WHO: World Health Organization
  2. *Percentages may not sum to 100% because participants may select more than one. All drugs are oral unless otherwise specified
  3. †Self-reported using the Pulmonary Hypertension Functional Classification Self-Report, © 2021 United Therapeutics Corporation [36], which was adapted with permission from the Pulmonary Hypertension WHO Functional Classification System
  4. ‡In addition to PAH-specific medications, 6 participants volunteered that they currently take a diuretic, and 1 participant each volunteered that they take the following supportive therapies: rivaroxaban, bumetanide, potassium chloride, low-dose aspirin, statin, calcium channel blocker, oxygen as needed